Confirmed: Original Antigenic Sin causes the growing waves

I’m going to have to break my self-imposed rule of posting once a day at most today. One thing I have said a looooooot of times, is that you needed to avoid this booster shot, because it is the stupidest thing you could do. See for example, November 14 2021:

If you do decide to boost, you merely kick the can down the hall until next winter. Everytime you inject someone with the same old version of the Spike protein, the immune system learns to zoom in more on this version of the Spike protein, to the expense of its ability to adjust to any novel variants that emerge. It appears to work well in the short term, as evidenced by Israel, but it’s not a sustainable solution, because you hamper the immune system in its ability to adjust to the inevitable further evolution of this virus.

You can look at my posts from late 2021, I was constantly warning about this, to anyone who might listen. I have also argued that the vaccines, through original antigenic sin, have caused the big growing waves of SARS-COV-2 reinfections in Western nations, not seen in those with low vaccination rates. And so you’ll have to forgive me, when I bring it up that the evidence available now proves me correct:

This is as bad as it sounds. The people who got boosted have a higher risk of an Omicron reinfection after their first Omicron infection, than the people who only got two shots. In other words, we have the evidence available here that vaccinated people are struggling to learn a new immune response from an Omicron infection.

So what about the unvaccinated then, who also have a higher rate than the two shot group? Well you have to realize they’re looking at people’s primary infection. If your first ever infection is BA.1 and you have no previous exposure to Spike, it’s not shocking that your immune response is so mild that you end up reinfected. The shocking finding here, is that the boosted are reinfected more rapidly than the double-vaccinated. It indicates they did something really stupid with this booster shot, which I already warned about a year ago (zooming in on an extinct version of the Spike protein).

And this is not some kind of nothingburger, a peculiar funny factoid for nerds to observe. No, this is how you tip a population over from herd immunity (it was possible) into a positive feedback loop of constant immunity damaging reinfections that enable further evolution. After all, the people who are getting reinfected more often are also exposing others more often.

I’m trying very hard, to come up with a post where I explain what the vaccinated can do to repair their immune response to this virus. The reason such a post doesn’t exist yet on this blog, is because I haven’t seen a substantial solution yet. That doesn’t mean there is no solution of course, it just means that I haven’t figured out what the solution would look like yet. The autoimmune problems are easier to address, what’s much harder is to figure out how one would go about addressing the improper antibody repertoire.

16 Comments

  1. What is your take on GVB’s latest “It is 5 past 12!” It seems like he has gone beyond OAS and imprinting. Thanks in advance!

    • I don’t know. Geert has been entirely correct in anticipating the failure of the vaccination campaign in the face of new variants that would evolve. Negative efficacy is real and it began very rapidly.

      I’m not entirely sure whether the virus still has the ability to trigger unprecedented waves of hospitalization however, rather than just continuing to cause accumulating damage, for reasons I explained below.

      It’s possible it still happens if people start getting hit by one variant rapidly after the next and hospitals have multiple variants circulating that fail to induce sufficient cross-reactive immunity. This is what Leonardi wrote about, the divergence that follows the current stage of convergence on completely antibody escaping mutations.

      • Isn’t the virus causing the very high hospitalization rates of kids in the U.S. and Canada now, indirectly, due to RSV, because their T cells are weakened due to covid infections? Unvaccinated little kids? I know that not being exposed to respiratory viruses for a while is likely also a problem, but I do know little kids who caught covid six months ago and now I’m wondering if they will be part of this huge surge of RSV in the state they live in, or if declining T cells will make the susceptible to other infections diseases. I hope I am just being propagandized by the zero covid people, but covid infection does seem to be a problem for T cells.

        • >Isn’t the virus causing the very high hospitalization rates of kids in the U.S. and Canada now, indirectly, due to RSV, because their T cells are weakened due to covid infections?

          Looks like it yes, unless you want to buy the “immunity debt” story.

          They’re constantly being exposed, regardless of whether they’re vaxxed or not.

  2. Would it be possible to make a vaccine with non-spike proteins from newer variants, and use it on people vaccinated with spike-protein vaccines from older variants?

    • >Would it be possible to make a vaccine with non-spike proteins from newer variants, and use it on people vaccinated with spike-protein vaccines from older variants?

      I don’t think that solves the main problem you’re dealing with, which is that people have antibodies binding to the wrong epitopes of Spike and the response is very similar in every vaccinated person.

      Neutralizing antibodies against Spike are an important component of the immune response, but they need to look different from one person to the next.

      Viruses discriminate against the common, in favor of the rare.

  3. I really appreciate your thoughts about the risk of cumulative damage to the hearts and lungs and brains and immune systems of the population due to constant reinfection with an evolving cloud of variants.
    If all this does is prematurely age people and reduce life expectancy from 80 to 70 it will have an enormous impact on society…but it could turn out to be worse than that.
    Geert seems to think that it is inevitable that a new strain will emerge that combines all the most worrying mutations we have seen in one package, plus some new mutations that take it to another level.
    If we get something with a 0.5% fatality rate in the middle-aged infecting the vaxxed 2-3 times per year that is enough to drop life expectancy to 40…if excess deaths get to 100% (mortality rates have doubled) as a result.
    And what could actually be worse is if it doesn’t kill that many people, but cripples them instead via damaging heart and brain function. A vast sea of unproductive people on disability. What if the vax does still prevent death…but you end up a physical and mental cripple.
    It is well understood in warfare that wounding a soldier hurts the enemy more than a killing a soldier, because of the resources needed to evacuate and care for the wounded. And I wonder how far ahead they were thinking when they cooked this weapon up in a lab.
    If we really do end up with a strain worse than any yet seen endlessly reinfecting people, the nightmare endpoint would be such a large portion of society crippled or mentally impaired, across the world, that civilization as we know it breaks down.
    Notions of human decency replaced by a triage calculation of who lives and who dies.

    • >And what could actually be worse is if it doesn’t kill that many people, but cripples them instead via damaging heart and brain function. A vast sea of unproductive people on disability. What if the vax does still prevent death…but you end up a physical and mental cripple.

      That’s what I expect.

      Large future waves of hospitalization are starting to look unlikely to me. If neutralizing antibody evasive variants like XBB and BQ.1.1 can’t do it, I’m not convinced the virus can still do it. It no longer truly catches people by surprise, the T-cells recognize it so there’s no pro-inflammatory cytokine feedback loop that runs out of control, so no ARDS.

      Rather I think we’re now getting accumulating immune depletion, blood vessel damage and brain damage, because although T cells still recognize this bug, they can’t keep the bug out on their own nor control it, they need neutralizing antibodies to do that.

      • There is a traditional Chinese medicine that is supposed to help rejuvenate T cells in old people, and there is at least one study on it. However, the study is out of China, and I have been told that their studies are even worse fabrications than ours (which is hard to imagine). But here is the study anyway; just because the study may be junk that doesn’t mean the treatment is worthless:

        Extracts of Cistanche deserticola Can Antagonize Immunosenescence and Extend Life Span in Senescence-Accelerated Mouse Prone 8 (SAM-P8) Mice
        Dietary supplementation of SAM-P8 mice for 4 weeks with 100, 500, and 2500 mg/kg of ECD was shown to result in significant increases in both naive T and natural killer cells in blood and spleen cell populations. In contrast, peripheral memory T cells and proinflammatory cytokine, IL-6 in serum, were substantially decreased

        (Evid Based Complement Alternat Med v.2014; 2014)

  4. “So what about the unvaccinated then, who also have a higher rate than the two shot group? Well you have to realize they’re looking at people’s primary infection. If your first ever infection is BA.1 and you have no previous exposure to Spike, it’s not shocking that your immune response is so mild that you end up reinfected.”

    Wait, I don’t get this. How is it not a problem if the unjuiced keep getting reinfected, but it is a problem if the juiced do? Or did I misunderstand you?

  5. “The autoimmune problems are easier to address, what’s much harder is to figure out how one would go about addressing the improper antibody repertoire.”

    Engineer a new virus that is the same as Covid except it does NOT have the spike protein.

    The immune system will react to the non-spike areas of this virus and create antibodies against them, which will give cross protection against covid.

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The patients in the mental ward have had their daily dose of xanax and calmed down it seems, so most of your comments should be automatically posted again. Try not to annoy me with your low IQ low status white male theories about the Nazi gas chambers being fake or CO2 being harmless plant food and we can all get along. Have fun!

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