Vaccination with vaccines that fail to stop transmission affects the evolutionary dynamics of pandemics. If you vaccinate someone three times with a particular variant of a virus, you can expect that a variant will eventually evolve, that figures out how to abuse original antigenic sin to its own advantage.
To explain once more, original antigenic sin is the phenomenon where the sort of antibody response deployed against a virus depends on the first exposure to said virus. If a new version of the virus then infects you, the antibody response you produce will be a derivative of the first response you made. This can be a less effective response, than if you had never been exposed to that virus before.
And that brings us to the XBB.1* family of variants, which are about 90% of all cases detected around the world these days. Thanks to a new study, we now know how this family of variants managed to take over the world: They have figured out how to abuse our immune system’s original antigenic sin mechanism to a maximal extent.
A number of animals were vaccinated, others were not, then the scientists infected them with different Omicron variants and checked whether the animals would still deploy a proper antibody response against those variants. And here you have the picture that shows you what they found:
On the left we see B.1.1. We see that both vaccinated and unvaccinated animals develop a proper antibody response after infection. Second from left we see BA.2. Unvaccinated animals develop a stronger antibody response than the vaccinated, but the difference is not very large. For BQ.1.1 the difference is bigger, that’s where we see a problem emerge: A number of the vaccinated animals just don’t produce any measurable neutralizing antibodies at all.
And then we arrive at the ugly part. They infected the animals with XBB.1. The unvaccinated animals deploy a normal antibody response against XBB.1 as a response. But the vaccinated ones don’t. Their antibody response is non-detectable in the majority of the animals. We also see that in the unvaccinated animals, the response against XBB.1 also works against XBB.1.5, suggesting protection from rapid reinfection in a real world scenario. In the vaccinated animals, the response against XBB.1.5 is also non-detectable.
In other words, the XBB.1* family is the family that figured out our collective hole in our shield against viruses, the nasty little place on the spectrum where our antibody response can’t block Spike because we’re just constantly deploying slightly mutated antibodies derived from our original response to the Wuhan spike protein. The evolution towards XBB.1*, is the evolution towards maximal use of the original antigenic sin humanity imposed upon itself.
The authors write:
These observations suggest that the induction of antiviral humoral immunity against a SARS-CoV-2 variant of infection is attenuated by comparatively-ancestral vaccine inoculation prior to infection.
In other words, if it wasn’t painfully obvious yet, mass vaccination was an act of borrowing from the future. The body has just become unable to deploy a proper antibody response against the XBB.1* family, it’s deploying the old junk from the Wuhan spike exposures, with some minor adjustments for subsequent breakthrough infections. And XBB.1.5 and its close relatives effectively represent the sort of Spike protein that escapes neutralization by such antibodies.
This study is not affected by the healthy vaccinee bias that most of the studies used by the industry to shill their products suffer from. Here we’re just looking at what happens at a molecular level, rather than comparing apples to oranges.
And I know nobody cares anymore, I know everyone has moved on. I also know the excess mortality has largely come to a halt. The virus is also largely missing now from sewage in most places.
But I think we’re dealing with a silence before the storm. It’s clear beyond any reasonable doubt now that these low IQ hypersocial conscientious morons have broken the population’s immune response: People are deploying antibodies, against Spike, from B cells that were activated by T cells that saw epitopes of the Wuhan spike protein. And because the morons gave everyone the mRNA junk, those antibodies become tolerogenic (IgG2 and IgG4).
We’re not dropping dead yet in droves, because people also have antibodies against non-Spike epitopes now and a CD8 T cell response against those epitopes, thanks to constant infections. But the response against Spike induced by these vaccines has become worse than useless: It has prohibited a proper response to Spike. Importantly, as I have amply documented, you would expect that these increasingly useless antibodies people deploy prohibited the NK cells from learning to do their job.
What’s happening now with the circulating XBB.1* descendants is that they’re changing all the other non-Spike genes. Some of that will serve to escape the CD8 T cells that try to kill infected cells, but more importantly, a lot of the changes are just meant to avoid the innate immune response.
Particularly, these mutations we see now are mostly meant to deal with the fact that a cell that is infected tries to ring all the alarm bells and draw attention to itself from the circulating white blood cells of the immune system.
What you can expect as a result is growing virulence. We don’t really have any reason to believe we’re selecting against virulence. If the virus evolves to stop your infected cells from ringing the alarm bells, it takes your immune system longer to figure out it’s time to get active. And if that takes longer, that means the virus can spread to more cells, requiring a far more aggressive immune response to get the situation under control.
The solution to that problem are the NK cells: They can recognize an infected cell is producing Spike proteins very early, they have special receptors to detect viral glycoproteins. But if you were vaccinated, your early infections constantly recalled those neutralizing antibodies against Spike, preventing the NK cells from learning to join the fight.
You would expect this to become a problem, as new versions of SARS2 now figure out how to make the infected cells stop sending distress signals (type I and III interferon and the downstream interferon induced signals) that attract the immune system. The NK cells would still recognize those infected cells on their own without needing the cell itself to raise these distress signals.
But… the NK cells are not there if they did not learn to join the fight during previous infections. That means they never got to proliferate themselves and take up residence in the tissues where SARS2 shows up. Instead you have the B cells and the T cells (the adaptive branch of the immune system) to fight SARS2, but those cells will only come into action in response to signals that they need to get active. If the infected cells themselves fail to send those signals because the virus got very sneaky, the NK cells need to be sending those signals.
Maybe I’m wrong, but I think I have a bit of a track record by now. I think I’ve clearly illustrated by now that they broke people’s immune response with these shit vaccines. I’ve demonstrated by now that the antibody response people now deploy against Spike is just improper, the wrong tool for the job.
This study here just further illustrates what I warned about, the problem of original antigenic sin and how a virus will just evolve to abuse original antigenic sin to its own advantage. It is now very clear that this has happened: XBB.1* is the sort of virus that abuses original antigenic sin induced by the vaccines against wuhan spike.
And what I warned you was going to happen back in 2021 has now been proven too: Eventually you would get versions of SARS2 that will make it more likely for vaccinated people to get infected than the unvaccinated.
And so I just want to make it clear here, that I think you’re going to witness increasing intrinsic virulence, as a result of evolution towards improved Interferon antagonism in the months ahead. It seems that Africa is quite protected against SARS2, because malaria infection seems to induce an NK cell response that’s also reactive against SARS2. In malaria, the NK cells get active even before the CD4 T cells.
Here’s my recommendation:
-Eat a healthy plant based diet.
-Consistently exercise, especially jogging on a treadmill.
-Eat natto high in nattokinase.
This is the best advice I can think of. I don’t know how you would go about repairing the NK cell response to SARS2, I can’t tell people to go off and get infected with malaria.
I’ve said many times before that this stuff needs to be studied: These low IQ hypersocial conscientious morons injected people’s children with their holy elixir. You want to know whether this has interfered with the NK cell response to SARS2.
Right now we just don’t know for sure. And nobody is studying it. We can only guess and speculate. If it’s true that the NK cell response is missing and if it’s true that SARS2 is evolving towards increased innate immune antagonism, then in the months ahead you would expect to see the start of the great unmasking: The discovery that these morons destroyed the most vital tool the body has to rapidly recognize the signs of an infection before the virus can spread.