I felt like offering you all a sign of life. There isn’t much left of me at this point. That’s what psychosis does to a human brain. I’m just not who I used to be a year ago. The SSRIs don’t work, the antipsychotics don’t work. Disco Elysium is doing what the SSRI’s are supposed to do. And so, when I have a blog that promotes the benefits of taking large doses of psychedelics, following an omega 3 deficient vegan diet andsoforth, I find myself realizing I’m perhaps not really an example others should follow. Maybe I’m the bad example. The thought goes through my mind sometimes.
But I can say, that it has all been an interesting journey. What keeps you up at night? What matters to you? Well personally, I want the world to go on living after I’m gone. That’s what matters to me. And it is threatened from two sides: Ontologically and physically. You can’t expect human beings, brains floating in skulls, sentience incarnated in matter, to function properly in a world that’s trying to build quantum computers and attempts to simulate intelligence on a computer. It’s not so much a recipe for madness, as it is a recipe for nihilism. What meaning can a human life have under these conditions?
But physically, that same world is of course threatened by a problem so obvious that people don’t want to hear about it. The transformation of our atmosphere, into one that is better suited to dinosaurs than to primates. With the course things are currently going, we have 25 years left of business as usual until the world hits three degree Celsius of global warming. That’s what the realistic projections that don’t severely underestimate the impact of a doubling of atmospheric CO2 say.
Think about what that means. It means any child that you or me puts into the world today, will be a young man, when he has to stare the reality in his face that this world will turn into a global desert. Right now this is something for nerds to discuss among themselves, but if you’re lucky to have a normal child, who is able to focus on normal day to day activities instead of gazing into the abyss all day long and writing about it on his obscure blog, he will still hear about it and it will still overwhelm his day to day experience of life.
I’m not saying that everyone is going to starve 25 years from now. You can survive off grains, good luck getting any chocolate or coffee though. No, I’m just saying that the world will be a nightmarish place, where life will feel utterly pointless and everyone will be depressed. Who wants to live when the orangutans are gone? How do you deal with reports of millions of people just dying in temperatures too hot for human survival, because the electric grid suffered a blackout during a heatwave? It will feel like God has abandoned this world.
So that’s your option A. And it doesn’t get better, that’s the fun part. It just keeps going. I know there are those of you who want to dispute this, I’m falling for Al Gore and Bill Gates propaganda, the soy burgers must have rotten my brain. Well look, I don’t make the rules. Any moron living in Switzerland can see what’s happening to the glaciers in his lifetime. At this point it’s all getting pretty obvious and what I notice is that the more obvious it gets, the harder it just gets for people to deal with it. You people deal with climate change the way you deal with your own mortality: You stick your heads in the sand.
But there is an option B. Option B is what I hope for. Not some liberal green utopia where everyone is vegan and rides his bicycle to work. I’m not that naive. No, I just hope for a crash. People die, nukes turn major cities into dust and the Earth gets a breathing pause. That’s a hard way to live your life. It’s hard to pick up the phone and talk to the customers for a living, if you think the customer should be vaporized in a mushroom cloud. But this is how I have to live my life. I am a man who prays for the Apocalypse.
And as you all must have noticed, we’re sorely lacking in anything apocalyptic lately. We just steadily continue our march towards the annihilation of our planetary life support system as eight billion big omnivores, while our nearest cousins, the Bonobo cling onto 30,000 to 50,000 individuals. There are too many of us by at least an order of magnitude, at least for us to live dignified lives. It’s not very dignified to live in concrete cubes stacked on top of each other, eating soylent.
I wish I could claim credit for this idea, but if I could press a button that unleashes a nuclear explosion on my city, I would happily press it, provided millions would die with me. And I like to think, that Mother Nature feels the same way.
After 2020, this blog gradually became about one single topic: The interesting human decision to deploy an inactivated vaccine that fails to train to properly train the innate immune system, against a novel SARS virus. Because for me, for someone who prays for the apocalypse, that is a source of hope.
I’m going to repeat the very basics for you. Antibody concentrations in the vaccinated remain about an order of magnitude above concentrations seen in the unvaccinated. In addition, we see expansion of specialized populations of natural killer cells in unvaccinated people upon infection. The immune response is simply fundamentally different between populations, changes that have persisted for years now.
I like to think they made a mistake when they vaccinated everyone. Why? Because I want your grandsons to throw spears at deer in the forest one day. I don’t want them gooning to their AI girlfriend on x.com. I’m obviously telling you a horror story. And that horror story, is one of a gradually deattenuating SARS virus. What sets the new coronavirus apart from its closest relatives, is that the start of its Spike protein, is unusually long. That makes it difficult for this virus to spread by fusing cells in your body together, but easier for it to spread from one person to another.
Fusing cells together is good for this virus, it allows it to spread without being detected by your antibodies. It’s bad for your body however, because your cells shouldn’t be getting fused together by viruses. This means that when the whole population depends on antibodies to keep these infections under control, you can expect the virus to evolve over time to get better at fusing cells together. That’s exactly what we see.
But you can dramatically increase this fusogenicity, by removing some parts of the start of the Spike protein, the N-Terminal Domain. All the other closely related coronaviruses have deletions there compared to SARS2. Those deletions, when introduced into the SARS2 virus that infects us humans, make the virus much better at fusing cells together.
Why would the virus delete parts of the N-Terminal Domain, if that makes it harder to spread from person to person? There are reasons to think of. Maybe the virus is being forced to survive by lengthening infections. Or maybe, there is strong antibody pressure on the N-Terminal Domain. The latter is currently the case. There’s a region targeted by antibodies.
In the newest SARS2 variant, BA.3.2, that exact region has been deleted. This BA.3.2 variant has already recombined in Australia with another variant. The recombination inherits most of the other variant, but it inherits the deletion of the NTD found in BA.3.2. It ditches the flaws and it passes on its shorter NTD.
So that’s what my money is on: I think we just witnessed the birth of a new variant in Australia, that’s going to behave like an actual SARS virus again, rather than a common cold. And again, I have to point out to you, viruses mutate and evolve. It accelerates over time, as the diversity enables further diversity.
The immune system functions the way it does for a reason. If the body wants to proliferate natural killer cells in response to an infection by this virus, it does so for a reason. That may result in more inflammation in our bodies, but that’s a price we have to pay.
A virus like this simply evolves in response to an antibody response, to evade that antibody response. First it evades the antibodies, then it evolves antibody resistance. We saw this with all the glycans, the sugar molecules that suddenly emerged on top of the N-Terminal Domain. Those block antibodies. Well, now we see it through deletions in the N-Terminal Domain. These deletions allow the virus to more effectively fuse cells together. That makes it deadlier.
Eventually, you’re left with an enormous antibody response that fails to work. In the absence of proper training of the innate immune system, that means the body won’t be able to control the infection. That then results in enormous amounts of sickness and death.
How do Africans manage to deal with malaria? Because their innate immune systems, particularly a subset of their NK cells, are trained through constant reinfections by the parasite. Those NK cells are flexible, mutations to the virus don’t really bother them.
Antibodies have a very specific purpose in nature. Their purpose is to promote health of the overall population, by discriminating against virulence associated epitopes in pathogens. In simple English: The purpose of our antibodies is to help mild versions of viruses to gain a competitive advantage over versions of those same viruses that hurt us.
In even simpler terms: When you vaccinate your entire population against a virus, there’s nothing left that encourages the virus to remain mild.
This is something you can see with influenza. We started vaccinating the elderly against influenza decades ago, but influenza deaths have not gone down. In fact, 2025 was the worst season so far. Why? Well when you vaccinate everyone with inactivated vaccines, you just help deadlier versions of influenza to evolve.
In the long run, it’s just not a good idea to vaccinate with these vaccines against these types of pathogens. It can not work.
We’re just not a species that is supposed to be getting constantly infected by SARS-type viruses. They’re not just magically going to turn into cold viruses.
Of course, this doom prophecy has been around for a while. I’m sure it feels dated to some of you by now. What can I say to that? Well, we see the genetic fingerprints of a coronavirus in East Asians, that spread among them for 20,000 years. It changed their genes. Something doesn’t measurably change your genes unless it’s removing a bunch of people from the population. But this won’t take 20,000 years to unfold, because there are now eight billion of us, churning out new variants simultaneously.
Allow me to pull up the Wikipedia page, for the viral quasispecies model:
Vaccines should include repertoires of B cell and T cell epitopes to evoke an ample immune response. The broad response should minimize selection of escape mutants that may be present as minority components in mutant spectra, as repeatedly documented experimentally.[10][22][44][70] With the current types of available vaccines, those that best comply with the multiple epitope requirement are, in the order of expected efficacy to confer protection against highly variable viruses: attenuated > inactivated whole virus > several expressed proteins > one expressed protein > multiple synthetic peptide antigens > single peptide antigen. The scarcity of effective synthetic vaccines for RNA viral pathogens despite huge scientific and economic efforts is a reflection of the underlying problems.
Do you see that? A vaccine that best fits the efficacy would be a live attenuated virus. If you don’t have that, your vaccine will be of limited efficacy against a rapidly mutating virus once it evolves sufficient genetic diversity. What we got instead was “one expressed protein”.
But it’s worse. You’re programming the immune system in the wrong manner. You’re arming soldiers against the wrong threat. I have explained this before, the antibodies are not even the proper class anymore at this point. The immune system is so confused about the threat it is dealing with by these vaccines, you’re left with IgG2 and IgG4 antibodies in your tissues against it. Those are antibodies you would normally deploy respectively against bacteria in your gut and allergens you are exposed to through your environment (like pollen from trees).
It can take a long time for the consequences to reveal themselves. I know it’s taking long. But the signs are there. The flu seasons keep getting worse. People are gradually getting sicker.
Vaccines sometimes just have the opposite effect of what their manufacturers were hoping to achieve. It happened with the Respiratory Syncytial Virus. It happened with the Dengue vaccines in the Philippines. It happened with the HIV vaccine trials. Well, they made the same error again, but now on a global scale.
Be patient. These things take time. But within a few years, things are just coming to a grinding halt. Since 2019, visits to the doctor for memory loss have doubled in Norway and Sweden. But they tripled for children. People’s brains are being damaged by this virus.
We’re going to see an interesting surprise emerge in Perth, Western Australia in the coming weeks. It’s almost here.