Don’t let your universe shrink

Nothing to see here, move along civilian

This is basically just a regular reminder, for all my friends.

Your universe, is the total range of experiences you can have. Whether that’s an itch on your toe, a vision in your head of a jungle covered planet circling twin stars, or sex with a beautiful woman, all of these experiences are your universe.

Your universe corresponds roughly to the total number of pathways between your neurons through synapses that ultimately lead into your claustrum.

And your universe is shrinking. Initially as a child it doesn’t really matter, your brain is getting rid of connections that you won’t really use. If that goes wrong, the brain fails to get rid of connections that don’t make sense, it’s seen in autism. It can result in conditions like being sexually attracted to cartoon ponies: Connections between concepts that shouldn’t be connected!

But around 20 or so, you increasingly start losing connections that are pretty neat to have. It’s nice to just be able to turn on the radio and enjoy new music, rather than being the sort of person only able to enjoy music you associate with your youth. “Remember, this is the song we danced to!” Yeah great, but how about being able to hear some kids play music in the local park and not be horrified by those electronic beepity boopity noises while you’re walking your dog? Well, keep those synapses!

Want to know how? Well, the humble cannabis plant is your friend:

A new study by Upstate Medical University researchers shows that recreational cannabis use may offer some protection against cognitive decline.

The study, by Master of Public Health (MPH) student Zhi Chen and Professor Roger Wong, PhD, MPH, MS, published last month in Current Alzheimer Research, analyzed a large data set from the CDC and found that compared to non-users, non-medical cannabis use, such as for recreational purposes, was significantly associated with 96 percent decreased odds of subjective cognitive decline (SCD). Medical and dual (medical and non-medical) use were also associated with decreased odds of SCD, although not significant. Cannabis consumption frequency and method were also not significantly associated with SCD.

SCD is an important outcome of interest as prior research shows individuals with SCD have a two times higher risk for dementia, which currently has no cure or definitive prevention approaches.

People are just really eager for some reason, to believe this plant is bad. They love to complain about the smell. They’re also terrified of what it might do to children, or in the womb. Well I’m sorry but if you fail to take this plant, you’re just going to gradually die, before your physical death. From your perspective it will just feel like your world shrinking. You’ll just find your life revolving around your obligations like your boring job and then when some weird friend or family member mentions something like the catacombs in Paris in passing and you’ll be shocked to just rediscover a whole concept you had forgotten about.

It’s not hard to understand how cannabis achieves this. As you grow older, your brain produces more amyloid beta. This is not bad, it’s used to capture stuff like metal particles and viral particles, so they don’t damage the neurons. But the amyloid beta turns into fibrils put together, toxic aggregates that destroy myelin, which insulates synapses so the neurons can rapidly communicate. But cannabinoids unfold these fibrils. THC pulls the fibrils apart, making them vulnerable again to destruction by enzymes, so your brain can get rid of the waste through its waste disposal system.

There is other stuff involved too. Cannabinoids prevent excessive synaptic pruning, that is, the loss of connections between neurons as we age. It is this excessive synaptic pruning, that plays a dominant role in cognitive decline, loss of neurons happens much later. As a result, your subjectively experienced world just stays larger. It has been well established by now in rodents, that very small doses of cannabis improve cognition in very old rodents, while higher doses improve cognition in moderately old rodents.

When you see the same results in lab animals as in actual humans, when you known of plausible biological mechanisms, then at some point, you just need to accept that this is a real phenomenon. Cannabis use in teenage years creates our good artists. Cannabis use in old age, prevents the decline into dementia.

With SARS-COV-2, people are now depositing large amounts of beta amyloid in their brain. The brain normally tries to clear itself of the amyloid proteins, but when they clump together, it gets harder to break down the amyloid. Unfold the amyloid with THC and the proteins become susceptible again to proteolytic enzymes.

There are two enzymes that are known to work well for this: Nattokinase and Serrapeptase. The combination works in rats to reduce Alzheimer’s, because it breaks down the amyloid protein (see also). It works better when the protein is deaggregated, that is, it floats as oligomers rather than fibrils. In other words, it’s more accessible for the enzymes after some THC.

We continue to see an increase in the Netherlands of people going to their GP, complaining of memory problems. The whole population is basically going through a process of accelerated cognitive aging. You have two guys running for president in the US of A with severe memory problems.

Excess buildup of amyloid is the first thing that seems to go wrong, until it eventually gets so bad that the effects become noticeable.

I just can not emphasize this enough: Once you start to notice memory problems, you’re already very late into the game. Long before you notice the memory problems, the amyloid beta begins to build up in the brain and your subjectively experienced world just starts shrinking.

That’s what disturbs me the most. Most people’s subjectively experienced world shrinks as they grow older, but they don’t really notice it. There is just less stuff you enjoy at forty, than you did at twenty. Your life begins to revolve around your job and whatever other obligations you have. The range of ideas you entertain in your brain and can derive enjoyment from just starts to shrink.

Ideally, you wouldn’t just take cannabis. Imagine you have a bunch of islands in the ocean. The total number of connections between villages will increase, as villages build roads from one side of the island to the other. But to increase the total number of connections further, you will have to build bridges, from one island to another.

A general pattern you will notice, is that the effects of cannabis work better, after you have recently had some psychedelics, like psilocybe mushrooms, DMT or Mescaline. It just gives the cannabis new stuff to work with.

I’m off to a festival tomorrow, so I probably won’t be posting for the coming few days, so I just want to point out to you again, that right now, we’re still in a big mess: The whole population continues to get repeatedly reinfected, by a virus that is damaging people’s brains. I’ll do a separate post on this again at some point.

I really recommend everyone, but particularly those of you above 50, to get yourself a vaporizer, that allows you to vaporize dried cannabis flowers. It’s not like smoking cannabis, it’s gentle on your lungs and a very pleasant flavor. Just take a bit of cannibidiol in advance, or mix it with some CBD weed when you vaporize it. The ideal time in my opinion, is after you went to the gym.

Ideally, eat some Natto and take some serrapeptase too. Now you are unfixating your immune system and unfolding amyloid fibrils in your brain.

You may feel a bit of a funny feeling in your brain, when you do this. That’s the amyloid being destabilized, it allows your endothelial cells in your blood vessels to communicate with the world again, it releases some trapped cytokines and unplugs clogging by amyloid junk in your brain’s lymphatic system.

The other thing I have to recommend, is to vaporize small amounts of DMT. It rejuvenates your mitochondria through the sigma 1 receptor and your neurons will store most of it for a few weeks in their vesicles, releasing it when they need it.

I have shown you all the numbers many times before, the population is starting to show growing signs of brain damage and premature aging. It’s turning LSWMs into morons, whose brains are filled with whatever they just read on zerohedge.com.

You can just go look back at the world before 2020, it was not this dumb. There was more diversity and nuance, in thought, in interests, in subcultures. Movies were better too. People were not coughing all the time.

So do yourself a favor, and don’t let your universe shrink. Everyone you ever met, every song you ever heard, it’s all inside of you, you’ve never experienced anything in your life other than the activation of certain combinations of pathways between your neurons. Take care of those pathways.