Like me, you may have been wondering how SARS-COV-2 will respond to escape the vaccine induced protection. History teaches us that vaccines deployed on a large scale in a population that subsequently fail to stop transmission tend to gradually select for the survival of more virulent varieties of those same viruses, as was seen with most of the poultry viruses like H5N1.
This is not a process that happens overnight, so most people are not very interested in it. The definition for excess mortality is changed, for 2025 the Netherlands revised it upwards a lot. Most people moved on from the topic altogether.
But just because most people now ignore the problem, doesn’t mean the problem is now over. For a virus to evolve in response to a vaccine, is a process that takes a few years. Eventually however, you’ll be left with a deadlier virus that you can’t really vaccinate against anymore. This is essentially inevitable. We know what it looks like in chickens, we have no reason to expect it can’t happen to humans.
There are eight billion of us. Even if no other route were to work to ensure its survival, in response to the population’s antibody response the SARS2 virus would simply evolve so much genetic diversity (the quasispecies model) that our lungs end up filled with a range of poorly reactive antibodies against it, leaving us with no defense against unrelated respiratory viruses. Why are countries like Japan seeing record excess mortality in the elderly in winter, accompanied by record waves of viruses like metapneumovirus? Here’s your answer.
But, as I documented earlier, the virus has now developed a second polybasic cleavage site, that overlaps the first cleavage site for furin that originally allowed it to conquer the globe. This second cleavage site appears to allow the virus to now use Matriptase as a cleavage enzyme.
The weirdest thing perhaps, is that lineages that used to be extinct, are now suddenly popping up again, but now with that newly added second polybasic cleavage site.
I find this very interesting, because it is essentially what also happened with the chicken influenza viruses that humans have been vaccinating those chickens against. As time went on, those viruses also developed increasingly longer polybasic cleavage sites, that made them more virulent.
Well, with the second overlapping polybasic cleavage site now seen in SARS-COV-2, you essentially see the same thing happen, although the higher virulence remains to be proven. You may wonder: Why does the longer polybasic cleavage site gradually result in a more virulent influenza virus? I wondered that too.
The SARS-COV-2 situation suggests to me the answer is: The longer you make the polybasic cleavage site, the more enzymes there are in the body that can find a proper site to attach. This increases the range of cell types the virus can infect, increasing the range of tissues that can be infected. In the case of chickens, this means you move from a virus that can infect a small number of cells in the lung, to a virus that can effectively infect cells found throughout the entire body of the bird.
In response to what I just explained, there are a number of questions to ask yourself. The first skeptical question would be: If these longer cleavage sites allow more enzymes to cut up a viral protein and thereby allow more cell types to be infected, why don’t all our respiratory viruses just move towards developing these long cleavage sites?
Well, in most of these viruses, you would expect antibodies to emerge specifically against the polybasic cleavage site, as it’s a region that looks different from our own proteins. But like must have happened with the vaccinated chickens, we already have antibodies against the Spike viral protein, so any attempt by the body at making antibodies against the polybasic cleavage site, would stumble upon pre-existing antibodies that block the path to the polybasic cleavage site (steric hindrance).
There is specifically a region close to the Furin cleavage site, that has a strong antibody response against it seen in the mRNA vaccinated, but not in the rest of the population. So in simple English: It looks like we already spent our gunpowder.
This is what I mean when I say: The purpose of antibodies is to discriminate against virulence associated epitopes. We know the 1918 flu did not endlessly return to kill millions more people. No, it gradually grew less virulent. Why did that happen? Well, at least part of the reason has to be searched in the survivors, who had very specific antibodies against the 1918 influenza for the rest of their lives, that are unable to neutralize other influenza viruses. Those antibodies would have been against epitopes associated with virulence.
This is what our population should have developed against SARS-COV-2: A small number of antibodies against specific portions of the virus, found only in very virulent versions of the virus, with higher concentrations of antibodies in response to more virulent infections, by more virulent variants.
We never developed this kind of virulence discouraging antibody immunity against the virus, because everyone was immunized against it with an identical Spike protein back in 2021. So now, when the virus develops a second polybasic cleavage site, there is nobody who develops antibodies against the new site, as everyone is already stuck with antibodies against neighboring regions.
Other questions to ask yourself include: This mutation was first spotted a year ago. Why would it only start to become dominant now? And you should ponder: Only certain lineages with a bunch of new glycans already added on top of their predecessors are starting to develop the second polybasic cleavage site. Why are only those lineages developing the new cleavage site?
Well, here’s one possible explanation. Matriptase is not just expressed throughout the respiratory tract. Matriptase is expressed in small amounts by your B cells and your monocytes. Those are both essential cells for fighting SARS-COV-2. Essentially, it seems that in addition to using TMPRSS2 to cleave the Spike protein, through the original cleavage site, it can now use TMPRSS6 (Matriptase) through the new overlapping site.
So we can see what happens. In the past, that is, about a year and a half ago when the mutation first emerged, an overlapping Matriptase cleavage site would have just resulted in this virus having its protein cleaved in the wrong manner, ending up in the wrong cell types where it can’t properly replicate. However, by now you see the mutation emerge on multiple rapidly growing lineages independently.
But now, there may be such strong antibody pressure, that the virus is forced to have particles that damage the B cells. The way to do that, would be by encouraging cleavage by enzymes produced by B cells, allowing the Spike proteins to enter the B cells. That could be achieved, through the new cleavage site that appears to render it cleavable by Matriptase.
When the B cells are being killed or damaged, that means you don’t get new plasma cells that produce novel antibodies against the virus. As a result, that should allow it to establish more chronic long-lasting infections. That would be visible as the sort of growth advantage we now observe.
This is what you have to remember:
- The new mutation that adds the second cleavage site first emerged about a year and a half ago, but it was simply a minority lineage that was wiped out again back then. So why is it now becoming globally dominant all of a sudden? Something must have changed.
- It now has an 11% growth advantage, when seen as added on top of LP.8.1, a lineage that already has a whole bunch of glycans added to it. There’s a second lineage where it’s doing well too.
- It seems that the new cleavage site only has an advantage in versions of the virus that had to develop a lot of glycans, to escape antibodies.
- This suggests to me, that we have now created the conditions in which versions of the virus become dominant that are able to damage the B cells that produce these antibodies, as simply blocking them is no longer enough to survive.
- If the virus as a whole retreats for the new few months, our antibodies will decline, but then the next wave is simply triggered by these new versions of the virus that are able to resist most antibodies and able to damage the B cells.
If SARS-COV-2 now evolved to do more damage to B cells, it’s a logical consequence of the constantly enduring efforts to vaccinate against it. At some point, evolving to avoid antibodies no longer works, as the body simply deploys new antibodies. You would then expect to see the currently apparently emerging response, to simply damage or kill the B cells.
That seems to be the point we have now reached.
If I understand correctly, some of your previous articles posited that once the NTD is fully covered with glycans, it’s checkmate for the vaccinated who cannot use their innate immune system, and can only use antibodies.
Now with the NTD covered in glycans, it seems that the virus cannot deal at all with the antibodies (opposite of what was posited), so it needs to bomb the antibody factories?
Or on the contrary, exactly because it can now checkmate the antibodies, it can approach the antibody factories? I.e. “Luftwaffe has been mostly destroyed, so now we can bomb the ball bearing factory we couldn’t reach before”?
Good question. I’m not sure about the answer. What’s clear is that it’s only now that suddenly all these new variants with an added cleavage site are emerging, suggesting that it’s only fit once the NTD is already covered in the glycans.
It’s seductive to think that you’re right and the antibody factories are now being approached because there are now viral particles with enough glycan coverage not to be threatened by the antibodies they secrete.
There’s not enough evidence for me to say definitively why this is happening exactly.
Brilliant analysis, as always. Thanks for posting another update.
So, if the B cells will be gradually killed off by these new lineages, and the immune system is characterized by “constrained space” (with different branches in competition with each other, as you’ve explained in previous posts), then perhaps the innate immune system of the vaccinated will finally get a chance to receive some training, which will hopefully then allow virulence to be selected against? So, a similar mechanism to your “cannabis hypothesis”, perhaps.
if the B cells will be gradually killed off by these new lineages […] then perhaps the innate immune system of the vaccinated will finally get a chance to receive some training, which will hopefully then allow virulence to be selected against?
If the innate immune system kicked in drive and defeated the virus after the new lineages exterminated the B cells… wouldn’t that mean that these lineages stopped spreading, because they are self-defeating? Wouldn’t the excess death curve go negative, as jabbies are left in better health by these lineages than before they were infected by them?
Killing the B cells would leave you open to all sorts of diseases, including cancer.
So perhaps they would finally be able to address the rona, but they will have massive mortality via other causes (including rona itself)
XFJ: https://www.youtube.com/watch?v=AngcdFxlHDo
Thanks for another clearly written, fine analysis. How did you understand all this without a formal background like Geert? Or maybe you are an undercover researcher that wants to keep your job?
The stakes of this game are really high. If a future variant, or another opportunistic pathogen, kills the jabbies by the hundreds of millions, life will become really dangerous for whoever tells the truth about what happened, in detail, and who the culprits are. I am happy to learn from Radagast whatever I can, and not ask him personal questions. That’s also why I am not trying to make this blog viral. A small blog drowned in the noise may be ignored, but one with tens of thousands of followers may become a dangerous hobby for his creator. Some of the popular writers who were covering the topic of decreasing birth rates after 2021 stopped writing all of a sudden for some reason.
>Some of the popular writers who were covering the topic of decreasing birth rates after 2021 stopped writing all of a sudden for some reason.
Like Igor?
Or, regarding vax deaths, like Brian Mowrey?
https://unglossed.substack.com/
The story has reached its denouement, I’m afraid
New narratives will be cooked up, it seems.
Oh, well.
Who wants to live forever?
https://youtu.be/UVcAFtQ-bAQ?si=wd0xixUP5NmAsIxW
https://pmc.ncbi.nlm.nih.gov/articles/PMC4102383/
This study says that fasting for 48-120 hours regenerates hematopoietic stem cells (HSC) and multiple cycles reduced the immunosuppression and mortality caused by Chemo and reversed age-dependent myeloid bias in mice.
I think there are other studies that suggest that fasting regenerates parts of your immune system, especially if they are mutated or damaged. I could imagine that between cannabis, fasting, and exercise that those would help a lot to boost the system.
Ok we have Igg4, T cell exhaustion and now the B cells are getting killed off. Not a lot left then. Any mention of memory B cell, losing them would explain why measles is going nuts in many different countries.
A very good piece. In the meantime, in addition to whatever new variant is incoming, despite very low wastewater levels, people around me are looking sick. Especially Asian people; or rather, they are aging like white people. I went to the post office today for the first time in months and the two nice middle aged Asian ladies who work there looked absolutely haggard and their skin had big wrinkles; that is not normal. Also I caught something on my visit to the East Coast; it is not respiratory (testing covid negative); it is digestive and I feel wiped out and ache a little all over, and it is lingering surprisingly long; usually I clear things very quickly. A really robust older guy I volunteer with, whom we rely on for a lot because of his energy level, now feels “weak.” I’ve lost track of how many times my sister in law and my adopted (genetically Asian) niece have been sick this year; it seems like it has been once a month. Even without Trump we will soon be back to pre industrial times, at this rate.
I got ill with something two weeks ago. Unjabbed, don’t care to test. I’m only just getting over it, but it has been horrible with uncontrollable dry hacking coughs.
RIP my IQ I guess
The common denominator my peers and I shared during Covid was short term memory significantly decreased after the initial symptoms went away. Nattokinase (thanks Radagast) and NAC (not sure what to think of it honestly) helped a lot.
all unjabbed btw.
Me too, it caught me off guard as it’s the only the start of autumn here. I suspect covid because my vaxxed wife was in close contact with someone who came down with covid after a trip to Brasil. At the same time my unvaxxed daughter got a cold, which she always gets at the start of the new schoolyear. It’s been 2 and a half weeks and still recovering. I’ve had bronchitis before, it can linger for weeks, but this is the first time I’ve experienced neurological symptoms, mostly dizziness. NAC didn’t help, Arginine apparently does, almost instantly felt relief. I’m unvaxxed.
Btw, I used CBD oil aswell, didn’t seem to help with the dizziness.
Thanks for the arginine lead. Apparently it crosses the blood brain barrier.
Inhibition of SARS-CoV-2 Mpro with Vitamin C, L-Arginine and a
Vitamin C/L-Arginine Combination
(“L-arginine was found to be active against SARS-CoV-2 Mpro, while a vitamin C/L-arginine combination had a synergistic antiviral action against Mpro. These findings confirm the results of our previous in silico repurposing study that showed L-arginine and vitamin C were potential Mpro inhibitors. Moreover, they suggest a possible molecular mechanism to explain the beneficial effect of arginine in COVID patients”)(“Arginine is a natural molecule that crosses the BBB”)
(Frontiers in Bioscience, Jan. 13, 2023)
I’ve read that people who have had herpes or shingles need to be careful with arginine (and foods high in it like chocolate and nuts) as it can reactivate the virus. I still take it even though I’ve had shingles but not in terribly high doses and at the first sign of any tingling where the rash was I discontinue and take ivermectin or BHT (info on BHT at https://projectwellbeing.com/steve
Arginine before infection makes you more susceptible
Should only be used after infection for endothelial concerns
Yes, on looking around I’m seeing that avoiding arginine is a treatment, too. Still, it is the only thing that I have seen anyone say helps with dizziness, so I will keep it in mind, since so many people have that problem now.
Exactly, it’s not a prophylactic, and I used it for the neurological symptoms as I had been almost constantly dizzy for 2 weeks, but since I started taking arginine (3 x 1,5grams) I’m feeling much better.
Wastewater tracking has its uses but it does not tell the full story. What you are noticing is the effect on society of living, eating and breathing in an environment perpetually contaminated with SARS-COV-2 and/or spike protein (in addition to the extremely high base level of general toxicity of our modern world). It’s shortening all of our lifespans. The only way to not be impacted would be to live off grid in the middle of nowhere and grow/hunt all your own food.
All diseases and pathogens are increasing in frequency due to the general immune compromised state of the population. The lying media likes to cherry pick things such as measles but everything is up.
This is why the Trump plan you mention is a fairy tale without first addressing the health crisis caused by the covid jabs. Who will work in the factories? Ironically, they would have start importing unjabbed Latinos again to get workers…
I read on X that 25,000 kids a day in America get a COVID jab. There goes the workers of the future too.
But wouldn’t this also be possible due to chronic infections (lasting several months), even consecutive ones, and not due to vaccination?
After taking Ohyasca, formerly radical leftist parents became Trump supporters:
https://www.reddit.com/r/QAnonCasualties/comments/1jvo5ld/leftist_to_conchristian_ayehuesca_parent/
Why did you 404 your last post:
Here was my comment:
https://www.rintrah.nl/not-my-turn-yet/
This is why Fauci does not give two-fucks now, and he never did, even back in 2020.
Fauci did however warn all those brain dead fuckers, including Trumpf.
Hence the smirk on his face, all the time.
And Fauci knows exactly what is coming, and he finds it funny, karma in a way:
https://slaynews.com/news/fauci-predicts-next-outbreak-coming-soon-warns-significant-morbidity/
This is RFK’s job now – to get the brain dead normie-tards to take the next vax.
>Why did you 404 your last post:
It was too bleak. Sorry, I really try to self-censor more lately now that I struggle so much with mental health problems.
I saw a part of a video of an interview of Fauci that was from about a week ago and as usual I had the sound off to not disturb my household and the first thing that I saw was that it didn’t look like Fauci. It looked like someone who had been chosen to look like Fauci. The facial structure was different and so was the skin tone and the wrinkles were different. Either this is someone else or it is the real Fauci smirking since he is on some magical med.
What did Rintrah say in the deleted post? Put in a way that is not too distressing, so that he isn’t made worse.
> What did Rintrah say in the deleted post? Put in a way that is not too distressing, so that he isn’t made worse.
+1
I can fix him
Unless he is gay, you cannot fix him.
Attention Glowies – send somebody over already – preferably a hot Swedish university student, with long fingernails.
Answered below.
For once, he hit the hammer exactly on the nail.
1) Climate change and ecological overshoot are not the problem, these are simply the symptoms;
2) Humans are the problem; and
3) Covid is, unfortunately (or fortunately as the case may be), the solution – karma in a way.
Kind regards,
Retard
PS – it was a good article – right on the money for a change. Pity that his Euro-glowie handlers pulled the plug and 404ed the post – but that is management for you.
Thank you. I regret not getting to read something Rintrah wrote (with a few exceptions), but relayed info is also good.