How SARS2 vaccination fueled the global Dengue epidemic

Bangladesh: Nearly 1,000 people die of dengue in severe outbreak

Floods and Heat Cause Peru’s Worst-Ever Dengue Outbreak

Dengue Cases Approach Historic Highs Worldwide; Local Transmission Seen In Europe

Brazil’s staggering dengue fever crisis is a warning to the world

You can read these articles for yourself, if you want to.

But personally, I’m more interested in explaining one thing. There are a number of differences between the SARS-COV-2 vaccines and almost every other vaccine human beings receive. When you receive a measles or polio vaccine, these vaccines are supposed to protect you from ever catching these viruses. In fact, when things go as planned, you’re not even supposed to encounter those viruses anymore.

That’s not the case with the SARS-COV-2 vaccines. These vaccines are sold to the public, with the promise of reducing the severity of a virus that will infect them twice a year or more, by maintaining chronically elevated levels of antibodies, as illustrated in the above image I borrowed from a Nature publication.

The idea here, the unspoken implicit assumption, seems to be that antibodies are like money in your bank account: You can’t have enough of them. But that’s just not how this works in nature. Once you move from petri dishes, lab rats and a couple hundred volunteers, to the real world, it becomes important to know how these changes interact with the world around us, which is full of numerous pathogens.

Because have a look at what we see when you look at what these antibodies do against Dengue:

Dengue disease is highly prevalent in tropical and subtropical regions worldwide. However, its pathogenesis is still incompletely understood, particularly in comparison to other endemic viruses. Antibody-dependent enhancement (ADE) is a well-known phenomenon for dengue viruses. Given the recent surge in dengue cases and potential cross-reactivity with SARS-CoV30 2 antibodies, this study explores the impact of anti-SARS-CoV-2 antibodies on DENV-2 infection. The study assessed the cross-reactivity of SARS-CoV-2 antibodies with the DENV-2 Virus.

Human convalescent plasma samples collected during different waves of COVID-19 and monoclonal and polyclonal antibodies raised against SARS-CoV-2 were examined for their potential to cause ADE of DENV-2 infection using cell-based assays. The study found that anti SARS-CoV-2 antibodies acquired from natural infection in humans or through experimental immunization in animals were cross-reactive with DENV-2 and had the potential to enhance DENV-2 infection in K562 and U937 cells. In-silico and in-vitro studies indicated a strong interaction between SARS-CoV-2 antibodies and DENV-2 E-protein, providing a molecular basis for these findings. This study is the first to demonstrate that anti-SARS-CoV-2 antibodies can cross-react with DENV-2 and can enhance its infection through ADE. These findings have implications for SARS-CoV-2 vaccine development and deployment strategies in regions where dengue is endemic

I’ve told you before, I look at this experiment like a student of nature would. Most people are asking themselves whether they’re going to get myocarditis or some other adverse effect. But I’ve said before, that the biggest problems take a few years to reveal themselves. This study was only published a few months ago. Until that time we just had speculation, like when I asked out loud what this abnormal IgG4 response is going to do to all the other pathogens circulating out there.

This problem is not something I invented myself after a high dose of Amnesia Haze, it’s just a basic principle of nature. It has been known for a long time: Live vaccines tend to provide protection against unrelated pathogens, by stimulating innate immunity. Inactivated vaccines on the other hand have the opposite effect, they reduce protection against unrelated pathogens, by interfering in the innate immune response. This is especially true, if they induce an IgG4 antibody response. I quote:

High IgG4 antibody levels generated in response to repeated inoculation with mRNA COVID-19 vaccines could be associated with a higher mortality rate from unrelated diseases and infections by suppressing the immune system.

There are a lot of things vaccine manufacturers and public health agencies asked themselves in 2021. I can guarantee you there is one question that did not enter these people’s minds: “What will this do to the global Dengue epidemic?”

They could have just done nothing. Some people would catch the first few variants, then eventually Omicron would come along and infect the rest. Most young people would never even have developed a detectable antibody response to the Omicron variants. Then eventually, the SARS2 viruses would have struggled to compete against the cocktail of other viruses that regularly spread themselves through our species.

Over time the intrinsic fitness of the virus would have declined, transmission would have been low enough to prevent recombinants from emerging that inherit the best of both worlds. In addition, people’s antibody response would have discriminated against virulent variants of the virus. But vaccinate everyone and there can be no discrimination against virulence. In the absence of active discrimination against virulence, virulence has a fitness advantage.

That’s the main thing that sets SARS2 apart, from the many other corona viruses that jumped into our species. For all the other viruses, people will develop a small number of high affinity IgG antibodies against specific regions of the receptor binding domain. Concentrations of those antibodies will depend on how severe their infection was. This means versions that cause severe infections bump into their own antibodies upon reinfection, whereas milder versions of the virus don’t. After vaccination the population has high concentrations of antibodies that are variant independent against conserved epitopes, so you don’t get this benefit of discrimination against virulence.

Unfortunately, this is the hardest thing for human beings to do: Nothing. And now the result may very well be, that you successfully introduced a new virus into Europe:

Cases of locally transmitted dengue on the European mainland were rare, as statistics collected between 2015 and 2019 show: European countries where the mosquito that spreads dengue is established, saw about 3,000 cases of travel-related dengue, but only 9 cases of local transmitted dengue.

But in 2022, cases rose higher than in the past seven decades on the European mainland combined — with 65 cases in France alone.

In 2023, the number of cases rose even higher — more than 110 cases, largely in France and Italy, and a handful in Spain.

I’ve said it before and I’ll say it again: The vaccines turned SARS-COV-2 effectively into a guest of honor in the human body. The body now rolls out the red carpet for it. This happened because the virus maintained those regions where infection enhancing antibodies bind, while changing the regions where neutralizing antibodies bind:

We analyzed … 16 anti-NTD neutralizing antibodies, and found that none of the anti-NTD neutralizing antibodies could recognize Delta spike … In contrast, when we analyzed the binding of the anti-NTD infectivity-enhancing antibodies … eight out of ten anti-NTD enhancing antibodies bound to Delta spike at levels comparable with wild-type spike …

I’ve seen many people on the Internet argue that “antibody dependent enhancement didn’t happen”. It did happen, it just didn’t look like what you thought it would. It led to constant waves of reinfections, you artificially turned SARS-COV-2 into one of the fittest viruses infecting our species. Those constant waves of reinfections damaged people’s immune systems.

But other pathogens may need some time, to optimally make use of the brave new world in which the whole immunological landscape is reoriented towards SARS-COV-2. You’ll encounter this problem for other viruses besides Dengue, if people bother to study it. The best candidate to study may be RSV.

24 Comments

  1. I’ve been recently re-reading many of your old archived virus/vaccine articles. This particular paragraph caught my attention:

    “You also see the NTD region, where vaccines develop a strong response. The NTD region evolves to optimally make use of these antibodies, they enhance infection. And most notable, you can see the purple category here, the people who were vaccinated after infection. Their antibody profile looks effectively indistinguishable from those who were vaccinated without prior infection here. In fact, it even looks as if they stopped focusing on the Fusion Protein region that works so well across variants.”

    https://www.rintrah.nl/a-poor-strategy-a-look-at-the-mechanisms-that-caused-the-sars-cov-2-vaccines-to-backfire/

    There are still many unknowns regarding how those vaccinated post infection will respond to future variants. They seem to be in a better position when compared with those vaccinated prior to infection, but just how much so is anyone’s guess really.

    One thing is certain however. What we now collectively face as a species will be orders of magnitude more disastrous than the ongoing Dengvaxia disaster in The Philippines. This is global. The fallout from the mass formation psychosis inflicted on humanity through 2020-2021 will be felt for decades. As Edward Dowd said in an interview with Greg Hunter on USA Watchdog:

    “We won’t be talking about this for the next ten years. We’ll be talking about this for the next two centuries. This is going to impact everybody throughout the globe for years to come.”

  2. Yes everywhere I go people are sick. Our garage hasn’t been collected a number of times lately and the website said “due to elevated levels of sick absentees”. NEVER saw that before. Also so many flare ups of autoimmune disease. we are in fuck up central now. so glad i am so stupid not to take the juice.

    • Yeah it’s remarkable how everything is now just starting to fall apart.

      They want to move from delivering mail daily to one every two days in the Netherlands now, because they have so many sick employees, so they’re asking the government to change the law.

      Not looking good.

      • yep, they did it in Germany already: now Deutsche Post is legally bound to deliver the mail within 3 days, while before they were supposed to deliver basically on the next day, provided you dropped it before 5pm (don’t nail me on the precise hour)
        Classes are cancelled on a regular basis because the teachers are constantly ill – I’ve got school-age kids so I know.
        Busses and local trains also often run on less frequent schedules because of too many operators are sick. It’s everywhere.
        The sickness leave stats are unequivocal: https://brownstone.org/articles/sickness-everywhere/
        You can see how the curve bends right there in 2021. In Germany the average sick leave days went up from 10-11 before 2021, to almost 20 in 2023. Almost double!

        Everybody, vaxxed or not, please do make sure you supplement enough Vit D. I personally use also nicotine and I am pretty convinced it helps, but can’t really know if it really does or I simply enjoy its stimulating effect. Can’t be too bad in small quantities: https://www.nature.com/articles/s41467-023-36543-8
        For the record: Radagast pointed at nicotine as a potential remedy a while ago!

  3. Highly vaccinated Ireland is seeing large numbers of RSV cases. It will be fine. We have vaccines now for RSV. What could possibly go wrong?

  4. You have the small, isolated failures at first, the systems capacity slowly eroding, then entire branches fail.
    You try to catch a flight out of a small airport but the aircraft is down for maintenance. The replacement aircraft is grounded while it taxis out, you end up flying home the next day from another airport.
    And months later I see panels separating in flight, major accidents, hydraulic failures, engine fires. Poor (or lack of) maintenance, impaired technicians and aircrew,Yeah.
    The few competent people left are overwhelmed. More fall ill, disabled, die.
    The wait time to see my doctors just keeps growing.

    • Trade work is near impossible to get. I am forced to do my own plumbing and roofing work, electrical work and car repairs now. YouTube is an excellent resource for car repairs.

  5. Rintrah, aren’t all those latent viruses we all have in us, like shingles, way more dangerous than Dengue and other exotic viruses?

    • Really depends how you wish to define “dangerous”. Herpes is pretty nasty if you’re eighty and don’t want to develop Alzheimer’s, but Dengue is a big problem if you don’t want your kids to get sick.

      • Quote: ” … if you’re eighty …”

        But that’s what I mean, it does now apply to all with damaged immune system, not only the older. If I google “how many latent viruses in humans” and combine this with the ruined immune systems many of us have, doesn’t this lead to an inevitable tsunami of illness?

  6. My first thoughts, just off the headline, without reading any of the article, is that dengue is going to be one bad mutha fooker.

    Vector borne man. . .

    Just you watch this space.

    Climate change, she’s a comin’.

    And with climate change comes an increase in the habitat for the mosquito vector for the Dengue virus.

    And as temps rise, they will bring that bad boy down further south, right to more populated areas of Oz.

    Tropical diseases have always been an issue down here.

    I can’t remember the figure off the top of my head, but maybe 5% of dengue fever expresses as hemorrhagic dengue fever.

    Mmm, mmm: ‘aint nothin’ like bleedin’ out all your orifices.

    I learned about this shit back when I was a man with a future – I broke down some 15 years ago I reckon. First, when I learned we were evil, then when I learned we were fooked 😛

    Anyway, back to the story, those mosquitoes are clever bastards. I forget how far they can crawl, in the dark, to reach a water source to breed in, but it’s a long fucking way.

    And now the story gets interesting. Australia is a dry country, so having water is a serious matter. So, the govt. offered/offers (maybe, it’s been a while) cash for people to set up water tanks.

    Now, we think we’re doing a good thing, but hidden in there is a problem (remember your Uncle Ted everyone – you cannot eat your cake and have it too), because now we have created a distributed water supply system, that is up to each tank owner to maintain.

    Do you think EVERYONE keeps the mozzies and their larvae out or their tanks?

    HA! HA! HA!

    In the old days, before the great stupid, and before climate change reared its ugly head, when an outbreak of Dengue came along, the inspectors used to check EVERYONES tank with an AXE!

    They’d bleed the whole lot out.

    I can easily imagine a compounding situation.

    Increased spread of dengue, which is worsened by some other factors (here’s looking at you “vaccines”, and ‘greenie’ style water supply solution initiatives) that end up wiping out whole areas.

    • It’s just a fucking shitshow.

      Honestly, how did we end up here?

      It must be partly due to a lack of violence.

      I know I wanted to brain that bitch who said to me, after I explained how we had a massive overconsumption problem, how what I’d said was “just one story”

      I should have clubbed her to death.

      Right there and then.

      With her own Cosmopolitan magazine.

      • Instead, we end up where we are now.

        The world got behind the ‘Cosmo girl/s’ despite whatever protestations were mustered, and for some weird as fuck reasons, she won.

        And now billions of us get to die.

        Strange as fuck.

        • And, to my shame, I didn’t go there.

          Sure, I would’ve gone to prison.

          But what is the life of one man against what is coming.

          • That’s what happens when you institutionalize a man I guess.

            They only get to tell you how fucked it is after they’ve fucked up.

          • Seriously, how did we get here?

            I had lectures in Fenner Hall, which was named after Frank Fenner.

            Frank knew a thing or two about extinction, he’d been responsible for wiping out smallpox.

            Before he died, he said he thought humans would go extinct, perhaps within a hundred years, but that he didn’t like to say anything about it because the dice were already cast and he didn’t want to make people feel bad.

            What. A. Cunt.

            I am here, right now, to tell you that if it don’t change, we are fooked.

            Can you change it? Well, maybe, but not without going mental.

            You can’t do it within the system.

            Change has to come from the outsider, who is willing to go the extra mile.

          • Not that I’ve ever had any real power or influence, and I’m not a god, so obviously not in control of events.

            Nevertheless, I feel like it’s a shame that it proved impossible to get fellow cogs in the machine to accept that it’s necessary to operate within limits. Instead, they went on promoting the usual nonsense – green growth etc.

            I guess everyone is supposed to self-censor heretical thoughts.

            Not that it probably would’ve made any difference anyway, even if we were allowed to talk about it, it’s probably all a bit too late, and it seems like were all too puny in the face of the monstrous scale of it all.

            Fenner was probably right.

            Sorry for the rant.

  7. That’s the way it is man.

    You are not allowed, within the confines of the system, to create solutions to the vexing problems of the day.

    Why?

    Because the system creates the problems, and if they go away, so does the system.

    So it stops you.

    It frames how you can act, so you can never solve anything, so it can keep operating.

    Which is fine and piratical way of going about things, until the throat that gets cut is yours.

    • My father, God rest his soul, was fond of this tale wherein the ruler of some town, who was brutal and greedy, was executed by having molten gold poured down his throat.

      You like it so much? You make our lives miserable? Then we ride down from the hills and make you eat it you goddamn BAZTARD!!!

      And that’s the kind of extreme it’d take.

      Who wants to go there?

      Yeah, I didn’t think so.

      And so, on we all march into the abyss.

  8. I feel bad for Brazilians. Bolsonaro was cutting down their rainforest, and now that the Marxists are back in charge, they’re going after the young kids:

    www dot chestermtam dot substack dot com/p/brazil-to-enforce-covid-vaccinations

    (December 7th 2023)

    “Compulsory COVID-19 Vaccination for Young Children: Brazil’s Controversial Initiative and Ongoing Debate”

    “In a significant move, the Brazilian Ministry of Health has included the COVID-19 vaccine in the country’s National Immunization Program (PNI) for children aged 6 months to 5 years. This decision, reported by Agência Brasil, signifies a step towards mandatory vaccination and contemplates the establishment of strict school vaccination centers.”

    What do they possibly hope to achieve with this? If this was December 2021, it’d still be a terrible decision, but not that surprising to be reading this sort of news. But December 2023? WTF?! The politicians opposed to these new mandates even invited Dr. Geert Vanden Bossche and Dr. Pierre Kory, among others, to speak out against the government on Brazilian television.

    Oh well, at least they’re really good at football. Except for that one time:

    https://www.youtube.com/watch?v=a7IMPsyQg6k

    (This is a duplicate comment, please ignore the original one Mr. Rintrah Radagast)

  9. Do open borders play a role in pandemics?

    This might be the subject I know least about, but I have a feeling that the wide open, bring everybody in, policy of Western leaders might allow things to spread more easily. Like a buffet for various viruses. “In this house, we believe a hard-working disease has the right to…”

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The patients in the mental ward have had their daily dose of xanax and calmed down it seems, so most of your comments should be automatically posted again. Try not to annoy me with your low IQ low status white male theories about the Nazi gas chambers being fake or CO2 being harmless plant food and we can all get along. Have fun!

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