So, as I have been documenting over the past few years now, we’ve seen a situation in which the new coronavirus, SARS-COV-2, become forced to evolve first into increasingly infectious variants (Alpha, Delta) with higher ACE2 affinity and then into highly antibody evasive variants (the Omicron variants). This then results in a population that has a relatively wide range of antibodies, to a wide range of Spike epitopes.
That results in a situation, where SARS-COV-2 becomes increasingly forced to increase its inherent antibody resistance. That involves the accumulation of sugar molecules (glycans) on the N-Terminal Domain, that prohibit the antibodies from binding that are now necessary for neutralization. This interplay between the vaccine, the immune system and the virus, is a process that takes many years to unfold.
What critical thinkers would ask themselves, is why we don’t just see every virus that regularly reinfects humans develop a bunch of glycans on its surface, if that allows viruses to render an antibody response useless. Logic would suggest there has to be some sort of cost involved for a virus, in covering a viral protein in these glycans that prohibit antibodies from binding to the protein.
This is a correct assessment. The innate immune system evolved various mechanisms to recognize basic patterns that pathogens and misbehaving cells in our bodies tend to display. As one example, our cells are forced to display small bits of proteins they’re producing in their MHC molecule on their surface. This allows your T cells to inspect whether they’re producing the right proteins, or whether their protein factory was hijacked by a virus.
Many viruses thus evolved mechanisms to interfere in this phenomenon, by stopping cells from displaying the MHC molecule on their surface altogether, so that the T cells can’t inspect what’s going on. The human immune system of course has to have ways to deal with that behavior of viruses. So what you see is that our Natural Killer cells, a population part of the innate immune system, treat it as suspicious when a cell fails to produce the MHC molecule, and weigh it as a factor part of their complex calculation on whether a cell should be killed or not.
The innate immune system has various other such clever mechanisms. There are specific molecules it produces, that allow it to recognize proteins that are unusually densely covered in these antibody-blocking glycans. These molecules are called Lectins. Lectins are what we call carbohydrate binding proteins that seek out sugar groups part of bigger molecules.
When it comes to the immune system, C-type Lectins appear to be the most relevant in our defense. These are proteins expressed by most cells part of the innate immune system. There are many different types of C-type Lectins and they tend to look specifically for proteins that have a high density of glycans.
That is, the recognition is density dependent. A normal protein part of our body may have some glycans, but a very high density of glycans on a protein reveals to the innate immune system that something weird may be going on that requires intervention.
As I have explained a few times before, natural immunity results in the expansion of the population of plasmacytoid dendritic cells, which recognize viral RNA and/or DNA. This is only possible when the first exposure occurs in the absence of an adaptive immune response induced by previous vaccination, as otherwise the B cells will just deal with an infection, before the plasmacytoid dendritic cells ever get to see the virus and proliferate in response.
When the plasmacytoid dendritic cells detect viral RNA/DNA, through their toll like receptors, they start to produce large amounts of Interferon alpha, which is a molecule that evolved to interfere in just about every step of the viral reproductive cycle. However, how much Interferon alpha they produce, is also dependent on secondary factors.
One of these factors, is whether their own specialized C-type lectin receptors like CLEC4C, recognized some protein that’s densely covered in glycans. If that is the case, they boost their interferon alpha production. For the plasmacytoid dendritic cells it becomes easier to realize it’s time to do their job, when the glycan density on the Spike protein starts to increase.
Another place where you see the innate immune system respond differently in breakthrough infections versus natural immunity, is in the brain. What you see here is that a population of monocytes gets to enter the brain upon infection, that does not get to enter the brain if someone was vaccinated before being infected. You also see an increase in Natural Killer cells and Dendritic cells in the brain.
The natural killer cells recognize whether a cell is infected by the virus and then decide whether the infected cells should be killed or not. But the monocytes and the dendritic cells also have an important job: Their job is to “eat” viral particles.
The dendritic cells try to capture viral particles, so that they can then degrade the viral particles with their lysosomes. But how do the denritic cells capture viral particles? They use their C-type lectin receptors for that!
In other words, what you would expect to see, is that as the dendritic cells now become faced with variants of SARS-COV-2 with more glycans on the Spike protein, they start to be able to do their job more effectively.
In essence, what’s currently happening is that SARS-COV-2 is being forced by the mass vaccination experiment, to evolve in a direction that makes it easier for the innate immune system to recognize the virus.
This is good for young people, as their innate immune system tends to be strong and capable. After all, it has to be able to protect them against all sorts of pathogens, as they normally don’t have any adaptive immunity yet against most of the pathogens that circulate (except for the passive adaptive immunity from breastfeeding).
You would expect this to cause problems however, for people whose adaptive immune system is mainly responsible for suppressing this virus. After vaccination, antibody concentration are about fifty times higher than normally seen after infection.
Constant breakthrough infections have not stimulated innate immunity. Rather, they just recall and broaden the adaptive immune response developed as a consequence of vaccination with non-live vaccines.
Once antibodies against the Receptor Binding Domain became unable to solve the problem, the immune system developed a type of antibody that targets part of the Receptor Binding Domain and part of the N-Terminal Domain (the N1 loop), to which the virus then responded with BA.2.86, which has a unique insertion mutation exactly in the part where these antibodies bind.
This BA.2.86 lineage wiped out all other lineages, revealing that most of the world’s population depends very strongly on the antibody response to keep the virus under control. The body then developed antibodies to this new version of the N1 loop, to which the virus then began to respond by putting the glycans on the N1 loop.
This is why you’re dealing with a situation where everyone keeps catching SARS-COV-2 and getting sick as a result.
All these elegant receptors our innate immune cells have to recognize glycoproteins like the Spike protein, like the C type lectin receptors, tend to depend on the Spike protein not being covered by antibodies. If there are antibodies on the Spike protein, those receptors bump into the antibodies, rather than managing to bind the Spike protein.
This is important to understand: If the antibodies are already on the job, they have to solve the job. And so when the virus has mutated to make the antibodies that bind to it of poor quality and to mainly keep around enhancing antibodies, that bind in places where they won’t stop the Spike protein from correctly binding to the ACE2 receptor, the immune system is forced to start targeting more and more regions of the Spike protein (immune refocusing).
Worst of all perhaps, some of these antibodies directed against SARS-COV-2, seem to cross-react with other respiratory viruses, like Influenza, where they bind to the glycans, but don’t neutralize the protein. So, these antibodies against SARS-COV-2, seem to be making it more difficult for the immune system to deal with other respiratory viruses too, because it’s just much harder for the C-type lectin receptors of the innate immune cells to bind to a protein when it already has these antibodies on it, particularly on its glycans.
You see an epidemic of various respiratory viruses around the world right now, sickening people at abnormally high levels. You need to be asking yourself, what the cause of that is. Some of it may be damage to the immune system, some of it may be due to antibodies against SARS-COV-2 interfering in the innate immune system’s ability to deal with those viruses. I already warned about this long ago.
The point I wish to make clear however with this post, is that it’s inappropriate to expect that the evolution of SARS-COV-2 towards a glycan-covered antibody resistant virus would increase its inherent virulence for everyone.
Instead, what you would expect to see, is that as these glycans accumulate on the Spike protein, the virus will increasingly begin to sicken people who depend on an adaptive immune response against it, whereas when the innate immune system handles the response to this virus, the impact on people’s health will start to decline.
Who cares about any of these details? Well, I’m explaining this for a reason. Immunologists are currently in the process of developing new types of SARS-COV-2 vaccines, that manage to evade recalling the original antigenic sin antibodies and encourage the development of new antibodies instead.
BUT THIS IS THE WRONG APPROACH!
You are very clearly dealing with a virus, that is increasing its glycan density!
And when a virus is rapidly increasing its glycan density, the immune system becomes increasingly dependent on the innate immune response to deal with it, as it just becomes easier to recognize it through the C-type lectins, while the most important parts of the virus for antibody mediated neutralization become inaccessible due to the glycans!
You have to figure out how to suppress the adaptive immune response, allowing the innate immune system to take over and do its job. I have seen just one approach that looks viable to me: Cannabinoids like CBD can suppress adaptive immunity, while encouraging NK cell activity.
It’s not coincidence, that you see better immunological functioning in HIV infected people with strong cannabis use. You see a DECREASED VIRAL RESERVOIR, in cannabis using HIV infected people. Because HIV rapidly mutates and establishes persistent infections, an antibody response is the wrong tool for the job. HIV already covers itself in a dense glycan shield.
Heavy cannabis use has the effect in HIV infected people of shifting their immune response to HIV more towards dependence on the innate immune system. For a respiratory virus like SARS-COV-2, which is still mostly targeting the lungs of vaccinated people, vaporized cannabis would seem like a proper candidate to me, to reduce the immunological abnormalities that were induced by vaccination. The terpenes are also known to have beneficial stimulating effects on the innate immune system.
Look, I understand this is just a weird blog, but look around you. People are coughing everywhere. They’re collapsing on stage. The hospitals are overwhelmed, there’s an epidemic of “walking pneumonia”, at record levels that have never been seen before since we started measuring in the 90’s. People don’t have to believe me, you can just connect the dots yourself.
This is not just some inherent trait of SARS-COV-2, it is mostly a consequence of provoking an inappropriate immune response towards SARS-COV-2. It really doesn’t have to be like this.
Unrelated but I have to point this out:
-It’s pretty clear to me by now that school shootings are a kind of contagious phenomenon too, a brain-virus that mostly spreads through the Internet.
So I have decided that I’m not going to make jokes about it anymore and I regret how lightly I treated the topic in the past. I’m far from perfect.
With the most recent school shooting, all sorts of popular Twitter users, who call themselves “journalists”, decided to start interviewing friends of the dead school shooter, so that they could gain access to the “manifesto”.
And of course when they get 10,000 likes for posting the manifesto, Elon Musk ends up paying them too. This is deeply unethical.
But nobody really benefits from spreading the “manifesto”. These shootings are almost always inspired by other shootings in the past. It was inaccessible, because the shooter made a mistake.
For the vast majority of us, reading a manifesto like this just satisfies our morbid curiosity, but for a small fraction, it encourages them to do something similar, it makes them feel like there are others who also saw this as a right way to deal with their anger.
A while ago I was reading about Jeffrey Dahmer, how you can find out everything about this guy, from his favorite music to his childhood friends and it made me realize we shouldn’t know so much about these people. But serial killing is now mostly extinct, whereas school shootings are a growing phenomenon. The more of these manifestos are circulating, the more school shootings we will see.
The trans kids are almost all either bipolar or autistic. The woke teachers are goading them into mutilating their bodies for sick political ends. No wonder they snap and seek revenge. When you’ve been physically and mentally abused, what more do you have to lose???
The solution is schools have to get back to teaching, and teaching only. No politics, no propoganda. Fire or jail these sick women.
Cannot believe there are actually people like you who think that compulsory public schooling was ever a healthy, wholesome thing. It was resisted with and ultimately imposed with armed force in its beginnings. It’s been industrial state kidnapping and indoctrination of children since it started, and now people with the collective historical perspective of a goldfish have developed Stockholm Syndrome for it. Insanity
I was pondering saying that. There is John Taylor Gatto’s book about it, or there is just the fact that practically everyone goes to school during their precious early years and comes out at the end with very little in the way of tangible talents to show for it. When I was at school it was often a zoo, so you couldn’t listen or concentrate, even if there had been much worth concentrating on.
There was at least “the cane” before my time, which would have meant it was quieter and less of a zoo.
Harrold is right though that it’s getting crapper and crapper.
Hearing JTG talk about it was a breath of fresh air for me back when I was about 16. Public school was a low security prison to me. Being forced to sit and do nothing while I waited for the classmates to catch up to me was truly painful. So much wasted time with nothing at all to show for it
Boomers are fine with slave indoctrination as-long as the indoctrination does not involve turning the kids gay. Unfortunately for them conservatives have never conserved anything; and the long march of the free market demands ever expanding identities to profit off of. Transgender people especially are very profitable to have around; and there are many programs to have their surgeries paid for by the state to the benefit of medical corporation.
School shootings are quite clearly the result of massive child abuse and the psychoactive drugs they dose abused children with.
These manifestos are garbage. In a society which was nice to children, they would be meaningless and ignored (though they wouldn’t even exist). It is only because people are abused as children that brainrot from other abused people can affect them.
“ Instead, what you would expect to see, is that as these glycans accumulate on the Spike protein, the virus will increasingly begin to sicken people who depend on an adaptive immune response against it, whereas when the innate immune system handles the response to this virus, the impact on people’s health will start to decline.”
Why will health decline when the innate immune system handles the response? I missed something…
“…the impact on people’s health will start to decline.”
The impact will decline.
Thank you for documenting this. Clear explanations. Outstanding work!
>People are coughing everywhere. They’re collapsing on stage. The hospitals are overwhelmed
From everything I can gather, it’s NOT those who remained unvaccinated against SARS-COV-2 who are suffering. It’s _only_ happening to the jabbed. To me this seems to be an important point. I don’t have the data but heard on a podcast that almost half of people tested are now asymptomatic carriers of SARS-COV-2. This blog has covered the IgG4 tolerance issue so that should not be a surprise.
So my take on this is a simple one: when they gave 80-90% of the population an experimental gene transfection they severely impaired the immune systems of that population and severely impaired the immune response to SARS-COV-2 in that population, which then prompted the tolerance and hosting of SARS-COV-2 in that population, which then prompted the evolution of endless new ‘variants’ of SARS-COV-2 that endlessly cycle through this population further weakening their already damaged immune systems. This weakened population is then prime to be sickened at higher than normal rates by all other diseases that impact humans.
Please correct me if I’m wrong.
There’s unusually high levels of sickness seen in children too, but most of them are unvaccinated.
But as the virus is now forced to start accumulating these glycans on its Spike protein, that should have the effect of easing its impact on young people.
I have two toddlers, both unvaxxed in the full sense. Wife and I are purebloods.
We are constantly sick with coughs in the past couple of months. UK.
It is difficult to know whether this is just what happens when you have children, or whether it is unusual. Not much we can do about it though.
I am in UK, and have 5 unvaxxed kids, one has been quite ill for a week recently, another before that, and the coughs. Walking pneumonia seems like a good description. I am taking vit c, d, b12 and some other things including nicotine and haven’t been ill since I last had covid in 2023.
A child’s innate immune system “army” is very large, but untrained.
That’s why children get sick more often; but then they adapt.
Anyone who is healthy and unvaccinated, and has lots of training through exposure, has a good innate immunity response: e.g. Health Care Workers, teachers etc.
Perhaps traditionally what you say is true, but SARS-COV-2 is a bioweapon. Exposure is cumulative in my opinion, and while some people have luckier genetics than others that makes them less susceptible, all evidence points to the fact that continued exposure eventually results in a breakdown of the immune system and serious illness. The groups you cite like Health Care workers have never been sicker! They are not getting more immune to COVID from all their exposures – the opposite is happening.
Right, Tibor. I had the traditional wisdom in mind.
On Covid, I thought the same thing would apply, but I don’t know. (Besides the need for unvaccinated to eat natto, for example..)
I can imagine HCWs who got vaccinated being sicker than ever. Does the same apply to unvaccinated?
But how does that comport with your statement that “whereas when the innate immune system handles the response to this virus, the impact on people’s health will start to decline”?
By saying “whereas” you seem to want to say the opposite but then say that unvaccinated health will decline? Is that an error?
Switzerland had 66%. On Paper.
And I swear on God in our constitution that I can feel the different vibes in trains. Remember: Public transport covers the more rural parts too while many trains jump from Milan to Berlin (or so.)
I swear it is the truth. Our underclass, migrants, workers and true rebels (an image of youth is wrong here) just sit there in the Regios, while the ICEs to Germany sound like a hospital.
>Constant breakthrough infections have not stimulated innate immunity. Rather, they just recall and broaden the adaptive immune response developed as a consequence of vaccination with non-live vaccines.
Why would this not apply to all vaccines for all diseases?
The other vaccines don’t result in widespread breakthrough infections that allows antibody evasive variants to evolve, before the antibody response to the virus in vaccinated people has undergone sufficient affinity maturation to prevent reinfections. In fact, because they vaccinated people with just a few weeks between doses, affinity maturation was basically halted, so the neutralizing antibodies maintained poor affinity.
And the main reason for the other vaccines not failing is because we only ever simultaneously vaccinate a small portion of the population, the young children.
Vaccination is a technology that works when it manages to eradicate a disease.
That’s what the promise was for the SARS2 vaccines: They would prevent infections and thereby deliver herd immunity.
But when that failed, the idea became to vaccinate to reduce the severity of a viral infection.
But that doesn’t work, as constant widespread breakthrough infections will result in the evolution of highly infectious vaccine evasive variants.
It’s infuriating the way leftist politicians jumped onboard the pharma bandwagon and tried to force EVERYBODY to get jabbed – not just in America but leftist politicians worldwide, for months and years after we knew it didn’t work.
They refused to look at the science and sneered at any skepticism as “misinformation.”
To this day there are institutions that still require injections of the experimental gene therapy that should have been banned years ago.
Affinity maturation is a trade-off between antibody specificity and conformation stability. Perhaps this was the reason for the small time period – who knows how their smooth brains operated at that time.
This text has a knowledge deep enough to be hard to understand for me. So briefly: The vaccination status is not what really matters, but if the immune system is working in “innate mode” or “adaptive mode” (induced by vaccine) If it is working in “innate mode”, then we could have the soldiers trained enough to get the situation under control. But if the immune system starts working in “adaptive mode” then it could be a problem and the virus is in the way to eventually says “checkmate”. Am I wrong?
No, you got it right, that’s basically what we’re faced with.
Do you think there are scenarios where a pureblood gets their adaptive immune system activated and is stuck with that response like a jabbie?
If you get reinfected enough times, from horridly infected sickly old farts with massive viral loads in, for example, long-term assisted living facilities, then your immune system will eventually bite, with enough reinfections from a high viral load carrier.
Original Antigenic Sin (OAS) is a state where the body keeps making prior variant antibodies (Abs) upon reinfection even though those Abs are useless, and fails to make an effective new Ab response.
With SARS-2 reinfections, the jabbed are making a wide range of Abs to lots of variants. The largest quantity of Abs targets the original Wuhan variant, with fewer and fewer Abs to each subsequent variant, until the fewest Abs target the most recent variant. The bulk of the immune response is directed to the older now-extinct variants. The quantity of Abs is abnormally high, and it’s the abnormal quantity that is the source of much of the interference with innate immunity.
Research has shown that the unjabbed make new updated antibodies when infected with a new variant (just like the jabbed), and the quantity of the new antibodies is normal (unlike the jabbed), and that the quantity of antibodies to the original Wuhan or other prior variants declines materially (unlike the jabbed).
This means that the unjabbed are not showing Original Antigenic Sin, while the jabbed are.
So the unjabbed (pureblood in your words) are getting their adaptive immune system activated, but because they aren’t showing OAS they aren’t stuck with the same unhelpful response that is seen in the jabbed.
If Retard has some data/research to add, I’d be glad to read it, but for now I’ll disagree. The more times the unjabbed are infected, the more efficiently and quickly the innate immunity works. If an unjabbed gets infected with a high starting viral load, that’s more likely to lead to an infection that goes deeper in the body (beyond the mucous membranes), and then the immune system makes Abs. But with the unjabbed, the immune system cuts production of old useless Abs and focuses on making new updated Abs.
So neither numerous infections nor deeper infections are going to cause the dysfunctional abnormal Ab response seen in the jabbed.
Do you think there are scenarios where a pureblood gets their adaptive immune system activated and is stuck with that response like a jabbie?
Not really in a manner that is going to be identical, because the virus would first be encountered by IgA and IgM, in the absence of vaccination.
mRNA vaccination bypass our natural barriers to induce an IgG response to SARS2, which then rises to such high concentrations that it actually starts to outcompete IgA in the lungs and in breast milk.
Thanks for posting another update.
I’m still a bit confused regarding the role of T cells in protecting the vaccinated against severe disease. You’ve written about how the virus evolves to reduce expression of MHC on the cell surface which renders the CD8+ T cells mostly useless. And obviously the IgG4 antibodies are interfering as well. And you’ve also described how the T cells induced by vaccination don’t secrete interferon gamma. And in your recent “Record Levels of Pneumonia” article, you shared that graph extrapolating CD4+ T cell decline in long COVID patients, which suggests that if current trends continue, things will start getting really nasty around 2028. Of course, this is all bad news.
But, if we just look at what will happen next year (2025) where most of the vaccinated population still has (somewhat) healthy levels of T cells, what will COVID disease look like in this population? Will the T cells be COMPLETELY useless against variants with increased glycosylation of spike, MOSTLY useless, or still quite effective? I am referring to both helper T cells and killer T cells.
Thanks in advance.
Pureblood is another term we should use in moderation. It is an arrogant term that projects superiority based on a single decision made during a person’s life. Not to diminish the importance of that decision (not to get the covid vaccine), but if you have ever had another vaccine or taken a lab-produced pharmaceutical, then you are not a pureblood. Also, with microplastics everywhere, none of us have pure blood at this point.
Why? It is just a joke aimed at the sensitive spots jabbies have.
They had all the same information I had, and i told them not to get it done.
Many jabbies went on to be vaccine fascists, so my sympathy levels are rather low.
I too have little sympathy for the people who have had a half a dozen or more vaccines despite the numerous signs of problems from them. I live in a very liberal area where the majority of people still get their covid (and flu) shots every fall. If you were to attempt to mock them by calling yourself a pureblood, they would think that you’re an idiot for not getting the vaccine. In other words, it’s a joke that most of them wouldn’t get anyway. My point was that most “purebloods” are only “pure” with respect to the covid vaccine. Most so-called “pure” people have probably had other vaccines and most likely have had one or more cases of covid by now. If so, they certainly aren’t pure in the sense of having never had the spike protein in them or taken a vaccine.
There are now propaganda articles, widely re-posted in aggregators such as Yahoo News and others, that teach us that in order to get protection from nuclear fallout, the public should “get inside and stay inside, ideally in a basement and away from outside walls for at least a day. Those existing spaces can provide protection from radioactive fallout” (source: https://apnews.com/article/nuclear-bunkers-war-atomic-bombs-0356fa5b34067c138c64b9143f73c308 ). So, forget about mass shielding from gamma rays, FEMA knows better. The drone BS thing also came with “news” articles that stated that Geiger counters showed “200 clicks per minute” in a location in New York (“clicks per minute” is meaningless without device calibration).
Most likely our rulers plan to blame the upcoming croaking of jab victims on radioactive fallout. Do y’all have a calibrated radiation meter, frens, to know what is fearmongering propaganda, and what is truth? If not calibrated, do you have multiple devices, based on different detection principles (Geiger vs scintillation? A gamma-ray spectrometer such as Radiacode?), that you can compare against each other? Reverse osmosis filters for the tap water in case of light fallout in water collection areas that you cannot measure? Printed-out tables with units conversions? Are you aware that there are cities in the world where the background is 30 micro-Sv/hr, and people are just fine? ( https://pmc.ncbi.nlm.nih.gov/articles/PMC6709356/ ) Something to keep in mind for when you will hear that “Radiation in the [US/EU] is x” (total BS, a fallout map looks like a leopard skin, averages are meaningless), or “it’s 100x background level” (do you know your background? In most places it’s something like 0.05 micro-Sv/hr)
https://www.thailandmedical.news/news/emerging-data-shows-that-united-states-is-facing-a-phenomenal-covid-19-surge-with-almost-750000-daily-infections
I wonder if the people running the world realized long term we’re basically fucked, nuclear war with russia not so scary anymore.
“As the United States heads into the final weeks of 2024, the country is grappling with a stunning resurgence of COVID-19 infections. Data from advanced modeling platforms, which analyze multiple sources such as the Institute for Health Metrics and Evaluation (IHME)-Washington, the U.S. CDC, and Biobot wastewater studies, are revealing an alarming spike in new infections. The United States is now experiencing an unprecedented wave – the 10th since the pandemic began – with daily cases nearing a staggering 750,000 and still rising. This wave, dubbed the “silent surge,” is being described as one of the most unexpected and explosive surges in recent memory.”
I wonder if my acquaintance who refuses to listen to me is infected with covid yet again, for the 4th or 5th time.
Thanks for this post, Radagast. Looks like there’s plenty of interest, which there blooming ought to be as everything looks to be hitting ‘turbo’. :-/
people: stop commenting on these depressing posts!!! we need more than 4 comments on billionarophobia or our host will get the wrong impression!!!
???? ⬅️ The two masks of Rintrah!
Stop worrying so much, I’m pretty sure he’ll do both. ????????????
First ???? was theatre emoji – tragedy and comedy
Second ??????????? smiley/upsidedownsmiley/sad face emojis
Hm
The stink comes from down under.
It has always come from down under.
Here is more:
https://www.cell.com/molecular-therapy-family/methods/fulltext/S2329-0501(24)00196-7
Another excellent piece.
One more person in my extended social circle just developed rapid onset dementia. A woman in her 70s who until recently had a perfect memory; she was able to recall anything. Last month it was a guy in his 70s who was one of the smartest people I know; now he recognizes no-one. This is bad.