So a few days ago I pointed out that all the excuses for the IgG4 antibody class shift after vaccination don’t hold up. We don’t see it happening in any unvaccinated people and we don’t see it happening after non-mRNA vaccination either. It’s a problem uniquely associated with the mRNA vaccines, which have been administered to more than 90% of the adult population in some countries.
I will have to address some more bullshit by the vaccine peddlers. I already know two or three people will read this post at most, but people asked me about this, so I will give them what they ask.
The idea being proposed by some is that IgG4 is together with IgG2 part of some normal compensatory response that inevitably has to happen after sufficient exposure to SARS-COV-2. But that’s not true. All the data we have suggests that there is no transition to IgG4 after infection. It’s not a normal compensatory biological mechanism.
The reason the IgG4 antibody class shift happened is because you gave people a “vaccine” that misrepresented what was going on to the immune system. The Spike protein was displayed on the surface of otherwise healthy cells in the absence of pro-inflammatory signaling, because these cells had been fooled into expressing this protein. When you do this often enough, you train the immune system to tolerate the Spike protein. It starts to think of those parts of the Spike protein that you want the antibodies to neutralize, as normal human proteins that need to be tolerated.
So the argument you often see peddled, is that this is not a problem, but part of a normal compensatory response, because there exist IgG4 antibodies against Nucleocapsid. But that’s not a valid argument and I will explain why. One of my commenters asked:
Now she sent me this study: Seroprevalence of IgG and Subclasses against the Nucleocapsid of SARS-CoV-2 in Health Workers ( https://www.mdpi.com/1999-4915/15/4/955 ) and I would be terribly grateful how to interpret this as they do show elevated IGg4 level in unvaccinated health workers against nucleocapsid protein and how that differs from Spike protein and how that applies (or it doesn’t) to latest IGg4 studies.
The answer is basically as following:
Your body produces IgG4 and IgG2 against stuff it needs to tolerate. Viruses typically evolve in a way that makes their proteins look similar to your own proteins, so that you can’t deploy an aggressive antibody response to those proteins without damaging your own body. For SARS-COV-2, the Nucleocapsid protein looks very similar to the Nucleocapsid protein in other corona viruses that regularly infect us. The Nucleocapsid protein has regions that look very similar to some of our own proteins, so you will find some IgG4 against certain regions when people are exposed to the virus.
However, this doesn’t matter much, because the Nucleocapsid protein is not the protein your body can use to neutralize the virus anyway, such antibodies can only help recognize infected cells and clean up viral debris. There’s a reason they vaccinated against Spike: It’s the only protein your can use to get antibodies that will neutralize the virus. Antibodies against the other proteins can not stop a viral particle from entering a cell.
In addition, we don’t see evidence of what these people are proposing, that the immune response shifts to IgG2 and IgG4 in response to sufficient exposure to the virus. This is not seen for antibodies against Spike, nor is it seen for antibodies against the Nucleocapsid protein. There are parts of the Nucleocapsid protein your body needs to tolerate, because they resemble your own proteins. Those antibodies may increase in concentration, but we see no evidence of a class shift to IgG2 and IgG4 against Nucleocapsid after SARS2 infection.
In simple English:
The immune system does not respond to SARS2 infection by learning to tolerate bits protein that it used to aggressively fight.
It keeps tolerating stuff that it already tolerated, sure. If the virus has sequences it tolerates, antibody concentrations against those sequences will rise, sure.
But what you don’t see, is the immune system moving from aggressively fighting certain sequences, to tolerating those sequences from now on. We have no evidence that this occurs in people, not even after severe infections from this virus.
That only appears to happen when you give people a bad vaccine, that makes the Spike protein look like just another normal protein that some of your own cells naturally happen to express.
They find that in healthcare workers, the detected subclasses were: IgG1 (82.4%), IgG2 (75.9%), IgG3 (42.6%), and IgG4 (72.6%). Why would IgG3 only show up in 42.6% of the healthcare workers? Because these workers were being studied outside of the context of any recent infection. IgG3 antibodies normally decline rapidly in most people. When you try to keep their levels high with regular booster shots, to protect people from reinfection, you start breaking stuff.
To understand these results and to find out if there is some sort of natural shift towards anti-inflammatory IgG2 and IgG4 antibodies, we can look at this study:
I’m going to quote the results for you here.
So yes, you see 9% antibody prevalence against Nucleocapsid. But you see just 1% with any detectable IgG4 antibodies against the Spike protein.
So is there evidence of some sort of class shift towards IgG2 and/or IgG4 in a severe infection? That’s the sort of situation where you would expect such a class shift to happen, if this is a real thing. So do we see evidence of it?
No. Not for Spike protein. And not for Nucleocapsid protein either. Look with me at this:
You can look for yourself here. There’s no evidence of a class shift towards IgG4. IgG4 and IgG2 increase in concentration as the infection becomes more severe, sure.
But look at IgG1 and IgG3, the normal antibodies you want to see. Their concentrations grow much more relatively than IgG2 and IgG4, for every protein! What you see is the opposite of a class shift: As the infection gets more severe, the body sends more and more IgG1 and IgG3 after those parts of the virus that look unlike any of your own proteins.
So why is there IgG4 detected against Nucleocapsid at all?
First of all, a lot of Nucleocapsid consists of sequences you find in all the hCOvs, as well as commensal bacteria:
COVID-19 patients elicit strong responses to the nucleocapsid (N) protein of SARS-CoV-2 but binding antibodies are also detected in prepandemic individuals, indicating potential crossreactivity with common cold human coronaviruses (HCoV) and questioning its utility in seroprevalence studies.
So when a part of the Nucleocapsid looks like something found in your gut bacteria, you will develop IgG2 antibodies against that part and perhaps IgG4. If you’re then infected by the virus, those concentrations will go up.
Second, parts of the Nucleocapsid looks like some of your own proteins, so of course your immune system can’t send aggressive pro-inflammatory antibodies after those parts:
We hypothesized that immunodominant epitopes of SARS-CoV-2 share homology with proteins associated with multiple sclerosis (MS). Using PEPMatch, a newly developed bioinformatics package which predicts peptide similarity within specific amino acid mismatching parameters consistent with published MHC binding capacity, we discovered that nucleocapsid protein shares significant overlap with 22 MS-associated proteins, including myelin proteolipid protein (PLP). Further computational evaluation demonstrated that this overlap may have critical implications for T cell responses in MS patients and is likely unique to SARS-CoV-2 among the major human coronaviruses.
You can expect your immune system to deploy IgG4 antibodies against these sequences. That’s normal, it helps prevent you from attacking your own healthy cells.
But when the immune response against SPIKE is dominated by IgG2 and IgG4? That’s a problem. It’s the only protein we know of, that allows your antibodies to neutralize viral particles.
Your own immune system never does that, not even after severe infections by this virus. Look at IgG4 against all the proteins in mild, vs moderate vs severe cases, in the graph I posted above. You don’t see the body switching to IgG4, against any of the proteins.
So sorry, the fact that you can find some IgG4 against nucleocapsid doesn’t bail us out. It’s not evidence that a tolerogenic class shift against Spike is a normal response to the virus.
Again, you’re still stuck with the worst case scenario.
You broke the antibody response, there are now amino acid sequences found in the Spike protein that more than a billion people worldwide were taught to tolerate. Every other pathogen now has a massive incentive to mutate, to incorporate those sequences people’s immune systems were taught to tolerate.
The other vaccines have failed too, they made the long term outcome of this pandemic much worse, by fixating people’s response on an extinct version of the virus. But there’s nothing quite as insane, as the failure of the mRNA vaccines.