I’ve written before about how we’re seeing signs of widespread brain damage in children. I don’t really like reporting on these things much. I would rather just post about more pleasant stuff. But the whole world now insists on pretending that none of this is going on, so I feel obliged to point out the problem to people who notice something’s wrong.
So, if long Covid was some kind of invention of hysterical cat ladies, as some like to think, then it’s pretty obvious what should happen. As time goes by, the number of cases should go down again. But have a look at what we actually see in children:
This is a doubling in the number of children with long COVID symptoms, between march 2023 and march 2024, a period in which everyone has started treating this virus like ancient history. How many doublings like this do you think we can afford to have until we’re left with nobody to keep the power plants running and the shelves in the supermarket filled?
The evidence is just clear: Something went wrong and it’s gradually getting worse. That’s why we see growing numbers of two year olds who can’t talk, growing numbers of kids who go to kindergarten with developmental impairment and growing numbers of children with long COVID. If the situation was stable I would move on to other stuff, but you’re dealing with a problem that’s steadily getting worse.
I’m going to point out again, that this is all a consequence of mass vaccination. My hope is that as the children now start to get chronically ill in droves, people will start asking themselves what went wrong, which means something can be done about it.
Almost all transmission is caused by obese elderly, this has been well studied, they exhale large amounts of aerosols. This causes healthy unvaccinated young people to suffer constant immune activation, which is particularly damaging for children. The immunological freeloading of the vaccinated places a high burden on the unvaccinated, particularly children.
We know why these vaccinated people constantly keep getting reinfected: They’re now stuck with a poor immune response against this virus. Most deaths in 2020 were caused by a very aggressive immune response to the virus. Vaccinate people and you will tone down that immune response, so fewer people will die initially, although the virus will return with a vengeance.
These waves continue to cause piles of deaths too, this week we have another spike in all age groups, 427 people in the Netherlands who died in excess. Here you have the number for all the past years:
These numbers are now stuck at about 15% above normal. The government is saving hundreds of millions of euros every year, because every year this country now has tens of thousands of excess deaths. But nobody is demanding answers, as to what’s going on. You don’t have to die to suffer the consequences of this problem, you could suffer a stroke or or develop long COVID.
If the problem was gone, if excess mortality returned to normal, the children stopped showing brain damage, there was no growth in long COVID cases, there were no waves of this virus in the middle of summer, there was no evidence of steadily growing virulence, we didn’t have an increase in strokes in young adults anymore and we didn’t see a bunch of new glycans emerge in the NTD, I would accept that I’m wrong and shut up about it.
But that’s not happening. How am I supposed to shut up about a problem everyone ignores, that’s killing 300 people every week, just in my country alone? If they died because they ate cheeseburgers, if they died because they didn’t wear a seatbelt, I would ignore it. But they die because they’re being deceived. And it’s a canary in the coalmine, for what is to come.
I’ve spent so much effort, explaining and demonstrating how the immune response has been impoverished. I’ve documented all this stuff, how people were left with enhancing antibodies that new variants of the virus continued to recall, without recalling the neutralizing antibodies. I’ve documented how the innate immune response is interfered with. I’ve documented how we’ve seen a class switch towards IgG4 and IgG2 against the receptor binding domain, which are not suited for neutralization at all. I’ve also documented the original antigenic sin problem, droves of people are just not able to develop a novel potently neutralizing antibody response.
And hey, everyone is just fine with the excess mortality apparently. But I don’t like it that we now have droves of children stuck with damaged bodies.
By now you should already know how it’s going to end: It’s going to end with a swarm of variants that are simply not affected by the antibodies anymore, mostly as a result of new N-linked glycans in the N-Terminal Domain of the Spike protein. That’s how the immunological freeloading that was achieved by some of the population comes to an end.
Well, that’s what’s happening. You had the summer wave, with variants that deleted S:31 to put a glycan on S:30. Now we mostly get variants that turn S:22 to Asparagine (N), to put a glycan on S:22 instead of S:30. That’s what “XEC” does among others.
But they’re already adding the next glycan on top: You now have a wave that turns 190 into Serine, which puts a glycan on 188. Some go for Threonine at 190, but that looks like a dead-end strategy. It demonstrates however how strong the pressure now is to add all these glycans on the NTD.
If you turn S:22 to Aspargine, turn S:190 to Serine and add S:A475V, which has independently been shown to be very fit, you get a variant with a big 108% growth advantage.
What you’re witnessing is this virus complete its glycan shield. Numerous viruses have such a glycan shield, that allows them to survive despite an antibody response in the host.
The point I’m making here is that you can just see the process, the birth of a proper glycan shield, happen in real time now: You can see all these glycans being added, which leaves you with a virus against which the antibodies won’t work. Because the T cell epitopes will be physically blocked by these glycans, the B cells won’t even be stimulated by CD4+ T cells to produce the antibodies anymore.
Nobody really disputes that there is now strong convergent pressure to add N-linked glycans to the N-Terminal Domain. But ask yourself: Why would a virus like this suddenly start adding N-linked glycans to its N-Terminal Domain? Why would there suddenly be a fitness advantage for such changes now, that wasn’t there two or three years ago?
The answer is straightforward: Neutralization now depends on antibodies against the N-Terminal Domain. That’s not how it’s supposed to work, it’s supposed to be IgG3 antibodies against the Receptor Binding Domain, but you already know what happened to those, they underwent a class switch.
The immune system developed a compensatory response, a strong antibody response against the N-Terminal Domain. The virus is now evolving to avoid that abnormal compensatory response. This is relatively easy, because the N-Terminal Domain is under less constraints than the Receptor Binding Domain anyway.
Most important perhaps is to note that none of this has to be perfect. We don’t know where the threshold lies and it’s likely to differ to some degree between individuals. SARS-COV-2 is capable of exhausting T cells, unlike other respiratory viruses. So when things get sufficiently nasty, there are feedback loops like this that start to accelerate the problem. Exhausted or senescent CD4+ T cells won’t stimulate the B cells, which then won’t go on to become antibody producing plasma cells.
The underlying problem of course, is that vaccination resulted in abnormally high concentrations of antibodies, fifty times higher than after a natural infection after just two shots. That’s what broke everything. These antibodies will interfere in the ability of the innate immune system to properly perform its job and improve its performance over time (training of innate immunity). They interfere in the ability of NK cells to learn to recognize the virus through their natural cytotoxicity receptors, interfere in plasmacytoid dendritic cells detecting the virus and interfere in monocytes migrating into different tissues, where they can mature into macrophages or dendritic cells.
You might wonder: If glycans allow the virus to avoid antibodies, why doesn’t every respiratory virus just develop a bunch of glycans that make the antibody response useless? Because there is a trade-off. Glycans can make it easier for the innate immune system to recognize a virus:
While N-linked glycans can contribute to neutralizing antibody epitopes, particularly in HIV,11 their main effect as large, immunologically “self” structures is to occlude the underlying protein surface. This means that changes in the glycan shield, with respect to the position of an N-linked glycan site and the processing state of the attached glycan, can modulate viral infectivity and hamper vaccine design efforts.12,13 Conversely, the presence of underprocessed glycans on viral glycoprotein immunogens, particularly of the oligomannose type, can enhance the interaction with the innate immune system and assist trafficking to germinal centers.14
At first, the response to these abnormally high vaccination induced antibodies is to mutate to avoid them. This then results in more recruitment of T cells and somatic hypermutation, to broaden the adaptive immune response to a wider range of epitopes, including increasing the response to the NTD.
Eventually, there is a class shift seen in the antibodies, to IgG2 and IgG4. This has now been documented for the mRNA and the Chinese inactivated vaccines, so it’s a problem that affects most of the global population. This class shift results in increasing undermining of the innate immune system. Before the class shift, NK cells can still recognize infected cells thanks to the antibodies. Such a response takes time, it’s slower compared to the cytotoxicity receptors they would normally use. After the class shift from IgG3 to IgG2 and IgG4 takes place however, the antibodies tell the NK cells to ignored the infected cells. NK cells can also be directly damaged, by the numerous breakthrough infections.
The result of all of this is that the innate immune system of most of the population is now undermined. It’s not just the case that people’s innate immune system failed to train against SARS2, it has been weakened by numerous breakthrough infections and high concentrations of IgG2 and IgG4 antibodies.
You can see signs of this from various lines of evidence, including the record levels of pneumonia observed in the population during winter:
Eventually the strategy of antibody evasion ceases to work for this virus, because people end up with very high concentrations of antibodies against a wide range of epitopes. That’s when the virus becomes forced to resort to adding new glycans to continue to spread. That’s where we’re now at. The added glycans we now see only emerge once the virus is under very strong pressure from the antibody response against the NTD, with no opportunity to evade those antibodies through simple mutation.
It’s not normal for the population to fail to develop lasting immunity against this virus and for this virus to display an unseasonal pattern. It disappeared throughout Europe in the summer of 2020, but since then it has caused waves of infections every summer. That’s a consequence of the adaptive immune system being forced to handle this virus on its own. France has just had the worst summer wave so far.
This is of course the exact opposite of what you would expect from a virus becoming endemic. If the virus is supposed to behave like another hCov, it’s supposed to settle into a normal seasonal pattern. This is not a problem that just solves itself over time, rather, it’s a problem that grows worse over time, as the antibody response gradually broadens to target less immunogenic epitopes. If you don’t solve this, the virus will solve it in its own way.
As long as the immunological freeloading by a share of the population continues, we place very high demands on the innate immune system of children exposed to these vaccinated people, whose immune systems are unable to control the virus. The closest thing I’ve seen to a solution is to administer high doses of cannabinoids, which discourage production of antibodies and force the innate immune system to take over. But this hasn’t been studied in relation to SARS2, so we don’t yet know if it works. I have been pointing out this problem multiple times now, but unfortunately nobody is interested in working on a solution.
What is the effect of all this, if any, on the unvaccinated who have also never apparently had Covid? Thanks.
I doubt there are any who have never had it, unless they’re completely isolating themselves.
I’ve never had COVID in 5 years of this “pandemic.”
You may say an antibody blood test could prove that I was an infected with the plague at some point but it wasn’t enough for me to even notice it.
I think the FDA should have been recommending cigarettes and whisky from the beginning instead of face diapers and crazy genetic injections.
Then the “pandemic” would have been done early.
The unvaccinated will be fine as long as they are in good health and didn’t live in isolation in the last four years. This is what Dr. Geert Vanden Bossche believes. However, there is a doctor from UK who’s name is Philip McMillan who doesn’t agree with Dr. Geert Vanden Bossche. If I were to bet on one of them I would definitely bet on Dr. Geert. He is the only doctor that I know about who has training and expertise in every single area related to pandemics: evolutionary biology, immunology, vaccinology and even veterinary medicine that is also useful. If I would be worried, I would start right away a Covid preventive treatment protocol.
Nobody, including this blog, talks about vitamin D. Get your blood level well over 50 and your immune system will handle just about anything. Provided you didn’t fuck it up permanently with mrna vaxeens, that you should have known not to fool with.
> people will start asking themselves what went wrong, which means something can be done about it
Those in power are still deep in denial. See the response that a courageous initiative to spread the truth received just recently:
https://jessicar.substack.com/p/this-is-the-modern-day-story-of-david
> Glycans can make it easier for the innate immune system to recognize a virus
This explains why the effects I have been feeling from shedding from the jabboids have become weaker and weaker over the past year. And why the amount of complaints about shedding I came across on the internets has waned away too over the past year.
t. pureblood — never tested, never jabbed
Rad, you’ve done a hell of a lot more than any of us. You gave me the knowledge, enabled understanding of what is happening to the people I care about.
somewhat off-topic: rr, have you heard of urolithin A? it’s a new supp on bro-science lswm twittersphere, supposedly for gainz and anti-senescence properties. it’s a post-biotic made by gut bacteria from stuff you get in pomegranate juice. i bring it up because supposedly it has has t-cell supporting properties that could help mitigate t-cell exhaustion. (https://www.cell.com/immunity/fulltext/S1074-7613(22)00508-8) i know you had predicted that will be a problem in the future. thoughts?
posted before reading, i guess it’s not off-topic since you mention t-cell exhaustion here. the linked study talks about CD8+ anti-tumor t-cells, not CD4+ though.
No thoughts. You can’t really draw conclusions based off one study. The T cell exhaustion is already a problem, it’s observed in droves of people.
I think there’s a chance cannabinoids can address some of the problem, because we see in HIV patients that heavy cannabis use suppresses their immunological abnormalities and a bunch of other studies back that up.
Nobody is really studying whether anything can repair the immunological abnormalities, but as long as nothing is done about the abnormal IgG4 antibody response against the RBD in the vaccinated, you can expect the problem to just get worse over time.
Good luck getting a significant amount of people on the Mary jane
true and it’s a mouse study. if you haven’t cured cancer in mice what are you even doing? it might be worth keeping an eye on… i know you’ve always got your eye on getting in early on the next grift. 🙂
Hi Radagast,
You say this: “. This causes healthy unvaccinated young people to suffer constant immune activation, which is particularly damaging for children.” but when I search immune system differences in children I get a lot of this: “The innate immune response of children is better at fighting coronavirus, which might help explain why they are less likely than adults to become seriously ill from the disease, new research suggests.”
That’s from this in 2022: https://www.standard.co.uk/news/uk/university-college-london-children-b973314.html
(The research was published in ‘Nature’)
So why do you say constant immune activation is particularly damaging for children?
Severe disease requiring hospitalisation is a different thing from long covid.
Long covid tends to strike predominantly very healthy young people with a strong innate immune system, like joggers who can run for miles.
Ok. So is the implication here that you need a Goldilocks ‘just right’ innate immune reaction to cope with this virus well? Too strong and you (can) get long COVID, too weak and you’re reliant on antibodies and that’s due imminent failure if you’re correct.
Is that about it do you think?
That is a reply to your above comment btw.
There’s a bunch of different factors involved. Exposure to a very high infectious dose, like when you work on an ICU, can also easily result in a severe form of long covid.
Similarly, after enough reinfections, people will also develop a long covid syndrome.
As long as the population does not develop herd immunity, long covid cases will increase.
As long as the elderly continue to be vaccinated, there will be no herd immunity. Herd immunity requires transmission to stop, which requires the innate immune system to be trained.
The vaccines program an antibody response that can work to keep severity of the disease low, but it can’t stop someone from getting infected, that requires elements of the innate immune system, like plasmacytoid dendritic cells and NK cells, that can recognize an infected cell before antibodies have attached to it.
At least not until we get highly glycosylated versions against which the antibodies are powerless, resulting in the deaths of people with degicient innate immunity.
Thank you, makes sense.
Thank you for posting another update, and trying to raise awareness of these problems.
> Glycans can make it easier for the innate immune system to recognize a virus.
Interesting, I was asking ChatGPT some questions about fusogenicity, and how SARS-CoV-2 uses the FCS to form viral syncytia with neighbouring cells. “It” told me that these large fused multicellular masses may not fully display/express stress-induced ligands on its surface i.e. these ligands may be somehow “diluted”, meaning that it would be more difficult for the NK cells to recognise and kill these fused masses of cells. Which would be problematic as it may increase the risk of persistent infections even in the unvaccinated. But hopefully ChatGPT is wrong about this.
>My hope is that as the children now start to get chronically ill in droves, people will start asking themselves what went wrong, which means something can be done about it.
Not going to happen.
The pandemic changed my perception of my fellow man on a fundamental level.
It might be time to start contemplating the horrifying possibility that the majority of the human population are *literally* NPCs.
>These waves continue to cause piles of deaths too, this week we have another spike in all age groups, 427 people in the Netherlands who died in excess. Here you have the number for all the past years:
I see that the BlueAnon/Scientism/Vaxxoids are still busy on Twitter posting studies like this one when anyone contravenes their Holy Writ:
https://pmc.ncbi.nlm.nih.gov/articles/PMC10357837/
“The pandemic changed my perception of my fellow man on a fundamental level.
It might be time to start contemplating the horrifying possibility that the majority of the human population are *literally* NPCs.”
Snap.
Stop blocking my comments Rad!!!
“I’ve documented how we’ve seen a class switch towards IgG4 and IgG2 against the receptor binding domain, which are not suited for neutralization at all.”
I found this study from Sept. 24, 2021
https://pmc.ncbi.nlm.nih.gov/articles/PMC8461218/#:~:text=In%20this%20prospective%20study%20we,mechanisms%2C%20yet%20to%20be%20verified.
Serum IgG4 level predicts COVID-19 related mortality
“In this prospective study we found that serum IgG4 level predicts a poor COVID-19 outcome. Based on the available literature, IgG4 antibodies may contribute to COVID-19 progression via at least two possible mechanisms, yet to be verified.”
High IGG4 levels predicted likely death.
So the IGG4 problem was known about before the Israeli study came out that promoted boasters on Oct 29, 2021.
Effectiveness of a third dose of the BNT162b2 mRNA COVID-19 vaccine for preventing severe outcomes in Israel: an observational study
Seems a bit odd.
Kids are killing off the vaccinated old people. Tern tweeted about this recently; somehow he just noticed it. He’s a dolt but good for anecdotes. Kids catch it at school, and infect grandma and grampa and kill them. The people Tern knows who are getting it over and over and over again are people with kids in school, and grandparents who live near their grandkids. That has a socioeconomic impact; poor and lower middle class and middle class people live near their grandkids; the kids are the great joy of their lives. Upper class people live far away from their grandkids since they are the sort of people who move for economic opportunity. That’s why you get so many Harris voters gloating about the disproportionate deaths of Trump voters.
In the Korean dog study, the dogs were not vaccinated and all of them sustained serious brain damage from a single case of covid. So even without the shots things would have been bad.
“Kids catch it at school”
Yep, school is a petri dish of infections. Kids can’t help but repeatedly catch it and infect their families – that’s how I got it twice. Ah, how I remember the health authorities reassuring everyone that children didn’t catch the virus, and that if they did, that they didn’t get sick. . .
The Parliament House in Oz got upgraded ventilation to cope with covid. Funnily enough, I haven’t heard of anything similar happening for the schools or any other public buildings. Why, my local school even refused to accept a donated air purifier. Ironically, the school didn’t think it would be fair for some kids to have better air than others. . .
Yes, that is what people are experiencing. Kids bringing it home from school. Obviously kids spend a LOT of time at school and at home. Even if they aren’t pumping out a lot of virus individually per unit of time, over enough time it is enough to infect. I really have no dog in this race, but it doesn’t seem that this is a collective hallucination.
“That’s why you get so many Harris voters gloating about the disproportionate deaths of Trump voters.”
In addition to the points you made about the potential reason for this, I wonder if there are also fewer children/families among Harris voters full stop?
Perhaps they are more likely to be white collar aspirational types who’ve studied for years and years and would rather have a career than a family?
>Kids are killing off the vaccinated old people. Tern tweeted about this recently; somehow he just noticed it.
Yeah tern is the archetypal progressive Christian boomer.
The science is clear on this: aerosols are a product of BMI * AGE.
The kids are the victims, the elderly and the obese are the perpetrators.
But that is just not what people feel they are observing. It at least appears very clear to people that kids catch it at school, and then bring it home and infect their parents, who are in their 40s. Do you count people in their 40s as elderly???? And that “elderly 40 year olds” are infecting the kids??? Do you think all of those kid cases, which go through classrooms, are separate parents infecting their own kids coincidentally all at the same time??? How does a classroom all get infected at once? Some old or fat person wanders by the group? Admittedly teachers in the U.S. are mostly fat, despite mostly being very young.
Wouldn’t aerosols be BMI*AGE*AMOUNT OF TIME OF EXPOSURE???? In which case kids re spreading it plenty, due to so much time in school. Twenty minutes with grandma, versus 12 hours around 30 other kids??
If amount of time of exposure is a factor, and how could it not be, then that would explain how humans survived other pandemics. They didn’t kill off their old people; they avoided contact with outsiders.
Perpetrator is not the right English word, since it means that the person is acting intentionally. Vector would be proper usage.
>But that is just not what people feel they are observing. It at least appears very clear to people that kids catch it at school, and then bring it home and infect their parents, who are in their 40s. Do you count people in their 40s as elderly???? And that “elderly 40 year olds” are infecting the kids??? Do you think all of those kid cases, which go through classrooms, are separate parents infecting their own kids coincidentally all at the same time??? How does a classroom all get infected at once? Some old or fat person wanders by the group?
The problem with children getting sick is that when they’re sick, it’s very noticeable. When children all get sick around the same time, you have to consider that they are all exposed to similar circumstances. This is true for the elderly too, weather extremes make the body more vulnerable. We can get sick, just by spending time outside in cold wet weather, as pathogens already present in our body benefit from the irritation.
But to be fair, the situation has also changed since omicron, with children getting more easily infected by novel variants.
I guess it’s hard to tease out cause and effect here. Could it be a case of vaccinated older people being more ‘incubators’ and the children being more ‘spreaders’? They basically play off each other and one thing we do know by now is that this virus is easily catchable by most.
Sounds plausible.
I’d have thought there’d be multiple angles: like people with “vaccine” gorked immune systems (not just the elderly obese) getting sicker for longer and making good incubators for variants; kids and whoever else who happens to get closed unnaturally into close proximity with each other for hours at a time get sick; obese elderly being super spreaders.
It’s interesting how bad practice upon bad practice seems to be compounding into a catastrophe, like the turn of events in an episode of ‘air crash investigations’.
The ‘neatness’ of it is attractive: an unnatural virus gets manufactured; an unnatural therapy gets developed to treat it; elderly obese people who should’ve otherwise died got vaccinated and survived, but they are now incubating/spreading variants (along with other immune suppressed people who got vaccinated??); people unnaturally fly all over the planet spreading it everywhere (Xmas is coming up again, with all the travel. . . ), rinse and repeat, and the gain of function exercise is well underway.
And again, concurrently, there is the bird flu in dairy cows, who were unnaturally fed industrial chicken cage scrapings, got infected, were subsequently unnaturally milked by machines, which further spread the unnatural disease udder to udder via teat cups, thus establishing another ‘gain of function’ experiment.
Has a chain reaction of progress traps started popping off? https://youtu.be/nM-_XaBVneE?t=31
What other traps will spring?
Judging by that video the ‘no sugar is actually worse than sugar’ trap has just gone off!
‘Artificial sweeteners as a sugar substitute: Are they really safe?’
https://pmc.ncbi.nlm.nih.gov/articles/PMC4899993/
“Ingestion of these artificial sweeteners (AS) results in the release of insulin from pancreas which is mistaken for glucose (due to their sweet taste). This increases the levels of insulin in blood eventually leading to decreased receptor activity due to insulin resistance.” From:
https://pmc.ncbi.nlm.nih.gov/articles/PMC7014832/
Yep. I’m not a fan of artificial sweeteners for this reason, not even of Stevia to be honest.
And yet I’ll readily drink my favorite ice tea, that has some sugar and some stevia in it.
I’m about the same – I just have sugar unless I can’t avoid it, then look for sugar/least damaging sweetener mix – which is always best if it avoids any nasty aftertaste.
That’s exactly it; there are just so many of these traps, all laid out under tension, just waiting for something to set off the chain reaction. The whole modern world is a progress trap.
The causal connections might not be obvious, or neat, but soon there could be so many balls in chaotic motion that it won’t be possible to determine which sets off the other.
I have heard a few commentators refer to this point in history as being ‘the quickening’ – a time of accelerating events (the Highlander theme seems apt here, as the nations of the earth gather for ‘Ragnarök’, for reasons that they don’t understand, to fight for ‘the prize’).
Apart from selling Pepsi, the ping pong trap example is used to demonstrate nuclear fission – how all that pent up tension can be released in a chain reaction that can go off explosively. . .
And here we are, all that pent up energy, linked together into one big unnatural whole, with the first balls in motion just waiting to land and kick off the reaction that will set off the rest and release all the pent-up energy in one big (and hopefully cathartic for everyone, or at least the survivors) explosion.
Wombat, that sounds very plausible.
The vaccine catastrophe is pretty much set in concrete.
Anyone see any way to break the bird flu chain?
I am just as worthless liar
I am just an imbecile
I will find a center in you
Trust in me and and fall as well.
https://youtu.be/nspxAG12Cpc?si=hctwoMyxFjtGvM65
I want what I want
I want what I want
Apollo, there is a repeating image in several Tool videos of a figure sticking his arm into a window or door, impotently grasping into the Void, grasping helplessly.
Does he find anything there?