We have known for some time now the mammal adapted H5N1 in cows in the United States is spilling back into the chicken broilers. This means you have essentially a complete circle: The virus liberally spreads between wild birds, cattle and chickens, so you will have mammal-adapted H5N1 popping up everywhere, making it easier for the chicken broilers to now pass on this virus to humans too.
That means you’re going to get a lot more cases of what we learned today, of three employees in a Colorado chicken broiler getting bird flu, with 48(!) more showing symptoms consistent with bird flu and getting tested.
New human adaptation associated mutations are beginning to show up in some cattle lineages from May onwards.
And it seems like we may be starting to see silent spread through communities too. Have a look at this. A guy who has been on Reddit for 12 years, who reports:
Kid on our baseball team had “pink eye.” My son and another kid got it. Then it worked our way through our family. Didn’t make the kids sick much beyond the “pink eye” but it out both my wife and I down for two days with body aches and what we thought was just pink eye. Wife tested positive in urgent care with a rapid mouth swab test for influenza A and negative for Covid. I just went in and said I think I got it and they gave me Tamiflu without a test. Significantly reduced the duration. Pretty sure we contracted it between each other through touch as it didn’t go respritorial until the pink eye subsided. Both my wife and I did bleed from our eyes.
Forget for a moment what the mortality rate of this virus is. You just don’t want to get infected by something that causes you to bleed from your eyeballs.
In a sane world, you would be shutting down the broilers and the dairy farms. There is no influenza virus like the polybasic cleavage site H5N1 variants, there is just no influenza pandemic we have ever lived through that behaves similarly. Not even the 1918 one had a polybasic cleavage site, so it could not infect people’s endothelial cells.
The Highly Pathogenic Avian Influenza is something that humans created, not nature. I quote:
It is unlikely for wild birds to develop HPAI from LPAI, but transmission of an LPAI strain (particularly an H5
or H7 subtype) to poultry may incite evolution into HPAI.
It’s influenza, in the sense that a bird is a dinosaur. Once it acquires a polybasic cleavage site, it starts changing its other genes too, to become a better fit for the new niche it has to survive in. It’s now stuck surviving in a situation where the optimal survival strategy is going to be entirely different.
You notice for example, that it’s much better at suppressing Interferon, than the influenza we are used to. This means the infected cells have a hard time suppressing its replication. You should not expect this to become a regular influenza over time: It entered into a different niche. If it somehow were to lose its polybasic cleavage site, it would still have the other genetic adaptations for its endotheliotropism, that require the polybasic cleavage site to function.
No, you can expect the opposite thing to happen: It’s going to grow deadlier over time, as it adapts to humans. That’s what we see with every other species it jumps into: It steadily adjusts to replicate better in the new host, growing deadlier as a result.
As long as people apply the influenza mental model, they’re just going to run into one surprise after another. Influenza doesn’t kill you by destroying your brain, but H5N1 does. This is what’s seen in all the carnivores unlucky enough to catch a sick bird.
This is a virus that evolved to kill at least 90% of chickens, within 48 hours of exposure. None of the normal influenza viruses do that, the birds fly around the world for days to spread those. This is a virus humans created, through decades of cruelty to chickens.
Over at statnews, they’re saying that schools need to prepare for the influenza pandemic they’re “likely to face”. With the way this is going, you’re going to have bird flu lockdowns eventually.
And rather than just wearing masks, they’ll have to make people wear masks and goggles to cover their eyes, as it infects through the eyes.
So you’ll basically end up looking like this:
You would have to cover your mouth, nose and eyes all the time. You would not recognize your friends and family walking on the street anymore, the cameras would not recognize criminals anymore. Nobody really wants to live like that.
But there wouldn’t be a real exit strategy either, because the birds flying around and the mice would still carry the virus.
I just really don’t get it, how they couldn’t figure this out, how they just thought they would techno-fix their way out of this.
“Well we accidentally created a new virus that kills 90% of chickens within 48 hours… and it’s spreading from the chickens into wild birds… let’s give them a vaccine and see if it works!”
“Oh it didn’t work… oh well, guess we’ll just have to kill the birds whenever it pops up. Hey, 90% of them were going to die in 48 hours anyway!”
“Oh it’s beginning to destroy endangered wild bird species…”
“Oh it’s beginning to kill all the babies of the sea lions in South America…”
Really people?
During none of these points, did any of the people dealing with this, think that maybe you’re going to need to radically rethink global food production?
You know it’s not just going to be H5N1, right?
H5 is just the family of Hemagluttinin genes that need to change least, to develop a polybasic cleavage site, the others can do it too with a few more steps.
There are other families of Influenza out there too, that can pull it off too, it’s just less straightforward for them, so it takes them longer. We just spotted the first case of a H7N5 outbreak in Germany a few days ago, a virus that we’ve never seen infecting poultry farms before.
These morons really seem to think they’re going to fix this with a vaccine.
You’ll give everyone antibodies against Influenza variant 1, then what happens is that Influenza variant 2 becomes the one that spreads around the world.
And hey, can I just point out again, that your food production model was going to have to change anyway?
“Yeah our chickens weigh twice as much as all the wild birds on Earth combined.”
What were you thinking?
You thought this could just continue like this forever?
Your cows, weigh 31 times as much, as all the wild mammals on land.
All the wolves, all the lions, all the mice, all the bats, all the hedgehogs, the polecats, the squirrels, the elephants, the deer, the kangaroos, the monkeys, smash ’em all together into a nice little bloody smoothie and it would weigh 3.22% of all the cows.
Why is this never announced on your nightly evening news?
Are they afraid that people will just lose their minds and turn into serial killers, when they realize we destroyed everything?
But it seems humans just really don’t want to see it.
In fact, if you label food that doesn’t contain meat, dairy or eggs as “vegan”, half of people who would otherwise eat it, don’t want to eat it.
Vegan is a dirty word to them.
Well, they deserve what they’re going to get.
In the Cyberpunk video game, animals (except for insects) are no longer raised for food, and the world’s wild birds have been exterminated after a terrible bird flu epidemic. Might be a prophecy.
Quote: “Well we accidentally created a new virus …”
Accidentally?
How do you know this is not a another creation of Fauci & Co?
>How do you know this is not a another creation of Fauci & Co?
Because I’m not an idiot.
It was first seen in China in the 90’s.
It evolved in the broilers.
Quote: “It evolved in the broilers.”
Bioweapon-Designers are also not idiots. I guess it’s easy for them to hide their spread in a way that you think it evolved in the broilers.
It’s really strange:
In climate things you’re totally focused on the man-made aspect, but in virus things you totally deny any man-made aspect.
>In climate things you’re totally focused on the man-made aspect, but in virus things you totally deny any man-made aspect.
Nope.
I don’t deny SARS2 came from a lab. It’s the most sensible explanation.
We don’t know of anything similar to it, we didn’t see isolated earlier outbreaks in humans of anything similar to it, it was genetically stable as it rapidly spread across the globe, its hexapeptide sequences resembled the human proteome and the mouse proteome and we know they were making humanized rodents to experiment on with SARS viruses.
Then there’s also the fact that the Wuhan lab behaved in a manner that suggested they were covering something up, they took down their database around the time the virus would have first emerged.
All of that suggests funny business/an accident. Either an accident in the Wuhan lab, or some actor is trying to make it look like an accident happened in the Wuhan lab.
But none of that is true for bird flu:
-We have known about this virus for more than 25 years.
-We watched it evolve in real time.
-We watched limited outbreaks in humans.
-We watched limited outbreaks in non-human mammals.
-We have observed how this virus evolves in the chicken broilers.
But LSWMs can’t accept what we know about this virus, because it means our whole system of meat production is unsustainable.
There’s nothing that special about the virus now popping up in cows. We watched it pop up in ferrets, we watched it pop up in the sea elephants and other aquatic mammals in South America, back in 2023.
Quote: “We watched it evolve in real time.”
That’s the point where I would do my insertion if I would be a bioweapon engineer:
Look around where natural evolving is at a point where i can use it, do my modification and bring it back there. Then everyone would believe it was all natural.
>That’s the point where I would do my insertion if I would be a bioweapon engineer:
>Look around where natural evolving is at a point where i can use it, do my modification and bring it back there. Then everyone would believe it was all natural.
All these mutations we’re seeing are single nucleotide polymorphisms we’ve seen spontaneously emerge multiple times, as far as I’m aware.
If you saw some weird insertion that has never been spotted before, fine, but I haven’t heard of that.
From a genetic point of view there’s more reason to think BA.2.86 came from a lab than the bird flu now infecting cows.
I wonder if there is already much undetected transmission happening on small non-industrial family farms, or even in people’s backyards/gardens where they keep a few hens that lay eggs.
So the chain of transmission may look something like:
Broiler/cattle pen -> wild bird -> free range hen
Well, it seems inevitable now.
It turns out, the new H5N1 variants figured out how to use the right sialic acid receptors.
https://www.nature.com/articles/s41586-024-07766-6
The host range of influenza viruses is determined, in part, by their receptor-binding specificity because avian influenza viruses prefer α2,3-linked sialic acids (expressed in the gastrointestinal tract of avian species), whereas human influenza viruses prefer α2,6-linked sialic acids (the predominant sialic acid species in the upper respiratory tract of humans). The 1957 and 1968 pandemic influenza viruses possess human-type receptor-binding specificity, even though their HAs originated from avian influenza viruses. The HPAI H5N1 viruses tested to date displayed avian-type receptor-binding specificity (for example, see 26-29 250 ); however, here we detected human- and avian-type receptor-binding specific for a bovine HPAI H5N1 virus, consistent with the finding of both sialic acid species in udders of cattle 30. Currently, we do not know whether this dual receptor-binding specificity reflects adaptive changes in cattle or is also a trait of other North American HPAI H5N1 viruses. Collectively, our study demonstrates that bovine H5N1 viruses may differ from previously circulating HPAI H5N1 viruses by possessing dual human/avian-type receptor-binding specificity with limited respiratory droplet transmission in ferrets.
This was the one thing it needed to figure out for human to human transmission, now it knows how to do it.
Now it knows how to replicate in the upper respiratory tract.
Buckle up.
Give it a rest buddy. Go obsess about something else.
Go away and read something else.
On a lighter note, here is a bit of a palate cleanser;
https://x.com/gunsnrosesgirl3/status/1812045820780306726
Solid plan. Vegans save industrial civilization and all modernity.
Human overpopulation is the root of almost every problem. The whole world is turning into one big farm, road, concrete-covered city and waste dump. The sustainable level is probably less than 10% of today’s number. The next mass extinction will correct this.
The earth’s rotational axis flips periodically every few thousand years. Then there will be a start over.
Quote: “All these mutations we’re seeing are single nucleotide polymorphisms we’ve seen spontaneously emerge multiple times, as far as I’m aware.
If you saw some weird insertion that has never been spotted before, fine, but I haven’t heard of that.”
Sorry, I have not enough knowledge to say something about your statement, because I’m not a virologist (and you too not).
But I stay with my point: It’s no longer possible to distinguish between natural driven evolution and lab-driven evolution, because they mix them together, since decades. And they are allowed to do what they want, and they can hire armies of helpers to make shit at hundreds of places on Earth at the same time, and can manipulate all data.
Therefore any “it’s all natural” statements are only “garbage in > garbage out” for me.
“Oh it’s beginning to kill all the babies of the sea lions in South America…”
I guess that means the mother sea lion is delivering live virus in her milk?
Ok if a mother gets a persistent infection would that not lead to extinction, long term tor a lot of different animals. There a bunch of articles saying raw milk causes sickness, but pasteurized doesn’t, so I would assume live virus in the milk.
Whether you get infected or not via the milk is not wholly the point. The viral proteins could render you vulnerable to other conditions.
Then again, this could exist for other things we do in our day to day lives. Whether this is uniquely damaging remains to be seen