The innate immune response in the brain

I’m guessing most of you who are unvaccinated must have noticed it by now. When you are around people who seem to have a persisting respiratory infection, who are constantly sneezing and coughing, you get a weird headache. Generally these people are vaccinated against COVID and blame their “allergies” for the fact that they’re constantly coughing and sneezing.

So what is that weird headache? Well it’s important to understand that the immune system in the unvaccinated responds differently than in the vaccinated. This has advantages and disadvantages. A new study in rodents again confirms this. It shows what I argued before, that in the unvaccinated, you can expect to see an increase in natural killer cells in the brain. This takes a while to happen, it’s a delayed response to infection.

The study finds that there’s a persistent population of dendritic cells and/or Natural Killer cells, that show up in the frontal cortex of the brain, at some point between 6 and 30 days after infection, as they’re found at 30 days, but not at 6 days.

I quote:

CD45highCD11b- cells, which are primarily dendritic cells or Natural Killer cells, were increased in number at 30 dpi, but not at 6 dpi, in the cortex (Suppl. Fig. 2e-f). 

If I were a charlatan, I would tell you this is all fine and dandy. But immunology is an endless series of trade-offs. The immune cells that migrate into your brain are going to be aggressive when necessary. What they found in this study is that upon breakthrough infections, there’s no real interleukin 1beta response in the brain, whereas there is in the unvaccinated.

These pro-inflammatory cytokines tell the brain to temporarily reduce the birth of new neurons, as dividing cells are much easier for viruses to infect and the brain needs to focus on defending itself.

This boost in pro-inflammatory cytokines is temporary, it returns to normal after 30 days. It’s mostly caused by the monocytes entering the brain. The monocytes in the brain are important in encouraging NK cells to enter the brain (hence why it takes at least 6 days before they show up).

Of course you have to keep in mind, that the white blood cells, particularly the NK cells that have migrated into the brain, entered the brain for a reason. They’re there to keep the brain safe, during any future encounters with the virus.

This is just not something you want to turn off. It’s a delayed protective mechanism that takes relatively long to develop. It’s there for a reason. NK cells take up residence in tissues where they’re needed and they adjust their behavior to become welcome guests in those tissues. As an example, in the central nervous system, NK cells release acetylcholine to calm down any excessive inflammation produced by infiltrating monocytes.

This in turn means that when you get re-exposed to the virus, these cells prepare themselves for that reality. There’s a particularly strong increase seen in cells migrating into the frontal cortex of the brain. So it makes perfect sense, that when you are exposed to high concentrations of the virus, you’re going to feel your immune system getting ready in the frontal part of your brain.

There are other things you may notice too. If the immune activation is particularly aggressive, you may notice yourself getting tired, depressed and/or anxious. When I sat in the bus, sleep deprived, on my way back to Holland, surrounded by coughing elderly, I felt miserable and exhausted for a week, despite having a great time at the festival.

You can also get a kind of swollen feeling in your sinuses, this also feels like a frontal headache. This is also a result of immune cells getting ready to fight. What can help then is inhaling hot moist air, particularly if you put some inhalation capsules in there, with eucalyptus or terpenes like pinene or menthol.

This is unfortunately just part of the brave new world we now live in. Since 2022, almost everyone in Western cities is just continually being exposed to a virus that has a habit of causing brain damage.

So what should you do about it? Well, it’s all kind of trial and error, isn’t it? What works well in people, what I recommended before, is to take a small (not a microdose) dose of Psilocybe mushrooms every once in a while. We have articles now where they ask medical experts how this might work, so we know a lot of people notice it’s doing something. There’s the obvious stuff, like physical exercise. You should go jogging from time to time, but wait a bit if you recently recovered from illness.

I also recommend people to take some cannabis at least once in a while. This allows your brain to get rid of the amyloid that builds up. There are other things that work, to quench excess inflammation in the brain. Salvia Divinorum has been shown to work to help inflamed blood vessels in the brain.

Of course, I have regularly recommended people to eat Natto. You can take Nattokinase, but I prefer to recommend eating real Natto, it has other enzymes and fermentation products the bacteria produce, that are known to help the body’s endothelial cells.

Obviously, you have to take good care of your teeth. You should brush and floss regularly, but you should also consider rinsing your teeth with some tea. All sorts of junk can get stuck under your gums, where it triggers constant inflammation in response to bacteria and viruses that can attack the brain.

Now specifically for people who were vaccinated against this virus, I have an important recommendation. Cannabinoids are important in regulating the immune response, they have a tendency to suppress an overly dominant adaptive immune response, particularly from mature B cells. This is the best available solution I have seen, to the IgG4 class shift problem.

Through cannabinoids like THC and CBD, the mature B cells secreting these antibodies are encouraged to undergo apoptosis, whereas NK cells and other arms of the innate immune system are encouraged to do their job. Listing all the evidence for this here would make this a very long post, I recommend you to look at this yourself.

Heavy use of cannabinoids, is the only thing I’ve seen that I think is a sustainable response to the faulty immune reprogramming induced by vaccination. One thing I will point out is that heavy cannabis use helps restore the immune balance in people living with HIV. It’s also observed that it reduces their senescent T cell population, while increasing the naive T cell population, which is what you want to see. It’s a general tendency that’s noticed, that cannabis helps address various (auto)immune conditions.

What the cannabinoids do can basically be thought of as telling an old dysfunctional adaptive immune response to get out of the way. That is of course, the exact problem that has to be solved in these SARS-COV-2 breakthrough infections: The vaccinated are stuck with an old dysfunctional adaptive immune response of T cells and B cells that have begun producing the wrong antibodies and constantly receive encouragement to proliferate again in response to breakthrough infections. This also forces any new T cells and B cells trying to join the fight, to focus on whatever parts of the Spike protein these old cells are not targeting yet.

As illustrated by this study I linked to at the top, the innate immune system has basically been side-lined in these vaccinated people, especially in the brain. It has not received an opportunity to join the fight against this pathogen, even though it will inevitably have to be the innate immune system that solves this problem.

We know how the immune system reacts to persistent malaria exposure: It develops a specialized population of NK cells that deliver people immunity against malaria, after multiple infections. These cells gradually decline again, once malaria disappears.

We also know how the body develops immunity to Dengue and Chikungunya virus: Plasmacytoid dendritic cells recognize the virus and activate the NK cells, thereby controlling the infection. Again, as I have shown before, the plasmacytoid dendritic cells and the NK cells spread into affected tissues and establish resident populations upon a SARS-COV-2 infection, but only if the host was not first vaccinated against the virus.

When the adaptive immune response fails, the innate immune system will not be able to jump in and solve the problem. As I cited above, it takes more than six days, before the NK cells and dendritic cells begin to migrate into the brain. It takes time and multiple exposures, for the innate immune system to properly prepare itself for infections of this nature.

This lack of a proper innate immune response in the brain is a problem that’s going to reveal itself once we start to see variants of the virus that systemically disseminate.

21 Comments

  1. Thank you for the advice.

    > This lack of a proper innate immune response in the brain is a problem that’s going to reveal itself once we start to see variants of the virus that systemically disseminate.

    This is something that I’ve been thinking about lately. You’ve written before about how there’s most likely an evolutionary trade off between transmissibility and fusogenicity, meaning that future variants with N-Terminal Domain deletions and glycans (what Vanden Bossche refers to as HIVICRON) will have a lower “R naught” than currently circulating highly infectious variants. Add to this the fact that vaccinated people infected with these highly fusogenic variants will be isolated from society, along with the return of lockdowns, which will drive down the transmission rate even further.

    But because there will be such strong selection pressure on the NTD, these HIVICRON variants will be emerging independently/convergently all over the place, in regions with high vaccination rates. So, they will still be spreading through the population.

    So what I’m still trying to understand is how long this “hyper-acute” phase (as described by Dr. GVB) will last, where we have this massive, massive HIVICRON wave, before we finally reach a stage of “*herd immunity**” where the majority of the population will be able to exert sterilising immunity to this virus, which will finally result in the end of the pandemic. So, I wonder whether this “hyper-acute phase” will last months, or maybe 1-2 years.

    * For argument sake, let’s just pretend for a moment that there are no animal reservoirs, like Delta in deer, that could potentially reintroduce the virus into the population at a future unknown date

    ** Dr. GVB actually believes that the pandemic will culminate in viral ERADICATION, not just viral endemicity/herd immunity

    • >So what I’m still trying to understand is how long this “hyper-acute” phase (as described by Dr. GVB) will last, where we have this massive, massive HIVICRON wave, before we finally reach a stage of “*herd immunity**” where the majority of the population will be able to exert sterilising immunity to this virus, which will finally result in the end of the pandemic. So, I wonder whether this “hyper-acute phase” will last months, or maybe 1-2 years.

      I wonder that too.

      You have to keep in mind that what happened in march 2020, was something very different from what we can expect in the future.

      The people who died, were mostly elderly who basically suffered a cytokine storm, an overly aggressive immune response to this virus, that destroys the tissues it seeks to protect.

      At the time people had basically no antibodies that recognized the viral agent, but everyone now has antibodies that recognize this virus.

      The problem we’re now dealing with is that people’s bodies will just struggle to eliminate the virus.

      I would be inclined to think that will end up looking more like something like tuberculosis or the first SARS and less like what we saw in march 2020.

      Tuberculosis tends to be latent in most people, until it eventually overcomes the immune system’s defenses, which then results in people getting sick for months.

      • So TB with a brainy component?

        Presidents and generals and nuclear submarine commanders slowly going insane?

        Clown world till the end!

        • >So TB with a brainy component?

          Well that’s basically what they’re measuring, isn’t it?

          They see brain damage in severe cases, along with lung damage.

  2. What are your thoughts on dosage/frequency/timing of CBD and nattokinase? I have tried eating natto, but it makes me nauseous. Also, do you think methylene blue has any protective benefits against COVID?

  3. So basically what you’re saying is, we need to segregate from the vaxxoids in order to preserve the white power in our brains?

    Somebody needs to run on the political platform of putting all vaxxoids in camps so that normal people can finally be safe. I’d vote for him in a heartbeat.

    • I don’t think that’s a good idea.

      Your brain will eventually have to learn to survive the bird flu too.

      This is just the end of the beginning.

  4. “The vaccinated are stuck with an old dysfunctional adaptive immune response…”
    First, thanks for you clear explanations that make it easy for everyone to understand these complex topics. I think I understand the roles that the adaptive and innate immune responses provide but in trying to connect the dots I’m still trying to figure out why the covid vaccines cause the innate immune response to be skipped and rely solely on the adaptive immune response. You might have covered this in the past but could you (or anyone else) recap why that happens.

    • >I’m still trying to figure out why the covid vaccines cause the innate immune response to be skipped and rely solely on the adaptive immune response. You might have covered this in the past but could you (or anyone else) recap why that happens.

      Yeah, I covered this long ago.

      It’s a problem with all non-live vaccines.

      The very short story is:

      NK cells have many different ways of checking whether a cell needs to be killed or not.

      One way is by checking whether the cell is covered by antibodies.

      But another important way, is by checking whether a cell is behaving normally or not.

      NK cells can learn to recognize whether cells are behaving normally or not, but this requires the virus to be actively interfering in the normal functioning of a cell, which it can’t do when it’s not live.

      In addition to this, there are the plasmacytoid dendritic cells, which can directly recognize viral RNA.

      Unfortunately, the vaccines were designed to only express modified RNA for the Spike protein, this RNA was specifically designed with very unusual nucleotides to avoid the normal innate immune response from the cells it infected.

      This makes it much harder for the plasmacytoid dendritic cells and the NK cells to join the fight. This is basically a double hit for the NK cells, because the plasmacytoid dendritic cells are also important in recruiting the NK cells to places where they’re needed.

      And normally infected cells would produce all sorts of pro-inflammatory cytokines and interferon alpha, because they recognize they were infected. NK cells often recognize this and then release interferon gamma, to help those infected cells get rid of the infection (without having to kill the infected cells).

      Then there’s also the simple fact that with injected vaccines, you just skip our natural barriers and basically immediately recruit an IgG response.

      In natural immunity, the virus first has to get through the mucous membranes, where it is exposed to IgA and IgM, before IgG ever gets to be involved in fighting the virus.

      So what happens is that the body essentially becomes very over-reliant on IgG antibodies to deal with the virus, with all other elements of the immune system basically being prohibited from properly learning to do their job.

      And when the body responds with a very strong IgG antibody response to something, without encouragement from the innate immune system (which gets active when cells are being infected), the body has strong reason to expect that it’s dealing with an allergen from the environment, rather than a viral agent.

      So what we see then is a class switch to IgG4.

      The reason none of this is properly solved during breakthrough infections, is because with these very high concentrations of IgG antibodies, along with B cells that will just immediately start producing these antibodies when an infection takes place, NK cells never really get a chance anymore to be properly educated: When they show up to the scene, an infected cell expressing the spike protein on its surface is already going to have that spike protein covered in antibodies.

      And it gets worse. Now that these antibodies have class switched to IgG4, the NK cells are basically being told whenever they see these infected cells with Spike proteins on their membrane covered by IgG4:

      “You are not needed here.”

      • The femoid tolerant IgG4 immune response vs the Chad Natural Killer Cell.

        “You are not needed here”

        *dies*

        It’s like pottery

  5. RR: I’m unvaccinated and my brain works fine. I’m not interested in the psychoactive effects of cannabinoids and psilocybins. Don’t want ’em, ain’t gonna use ’em. But I want to give my brain every chance of staying as good is it can be for as long as possible. So are there any preparations of these chemicals that will give me the brain-healing benefits without the tripping?

  6. Pretty sure that when GBV says the pandemic will only end when we reach herd immunity, he means that all of the people who are incapable of sterilizing the virus will have to go. Not a pretty picture

      • So far so good regarding the headaches. I had asymptomatic covid and only had my first symptomatic cold this year since 2015.

        totally off topic but I got balls deep in the not eating margarine and having more omega 3 to stave off sunburn. considering no one used to use it 50yrs ago.

        didn’t apply any yesterday and almost none all summer and was out at the lake all day (also a lot in the shade)
        got slightly red on my back. that’s it. a year ago that would have turned me into a lobster. you are what you eat.

  7. I wanted to share my personal experience, having just gotten over COVID for the second time (1st was in Jan 2022). I am not vaccinated. I’m a woman with a regular cycle, not on any form of birth control. My cycles are very regular; I track them and they are regular within 2 days every month. Both times I had COVID, my period started within a day of the fever, though my period wasn’t due. The other thing, as relates to your post, was unusual mental symptoms. Unusual in that, these are not symptoms I deal with. The first infection, I remember it was like a black enraged depression settled over my mind, which lifted after a couple of days. This more recent experience was more unsettling – nonsense phrases repeating in my head while trying to fall asleep or when waking up, mild visual hallucinations, things that made me wonder if I was suddenly schizophrenic. These began occuring about a week after my symptoms had subsided.

    People who write COVID off as ‘just’ the flu or no different than any cold maybe had different experiences than I did, if they ever had COVID. I’ve had influenza A more than once while I was quite sick, in fact, felt much worse during the illness than I did with COVID, and had a higher fever of longer duration than with COVID, no flu, and certainly no head cold ever made my menstrual cycle abruptly start or cause such strange and disturbing mental symptoms along with it.

    • Well, that isn’t cheering. You might use Xlear and claritin and nasal neosporin (google “covid Yale nasal neosporin) to try to keep from catching it over and over again. I know Rintrah says there is value in building up immunity via catching it, and he may well be right, but that’s not the path I’m taking.

    • >The first infection, I remember it was like a black enraged depression settled over my mind, which lifted after a couple of days. This more recent experience was more unsettling – nonsense phrases repeating in my head while trying to fall asleep or when waking up, mild visual hallucinations, things that made me wonder if I was suddenly schizophrenic. These began occuring about a week after my symptoms had subsided.

      Yup. It does something with the brain.

      It could just be because of sleep deprivation from the infection. Or there can be other mechanisms involved.

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